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宫颈癌术前辅助治疗30例临床分析

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摘要 目的分析局部晚期型宫颈癌术前辅助治疗方式。方法选取宫颈癌ⅠB2~ⅡA期患者30例为A组,术前施行BVP方案(DDP 30 mg d1~3,BLM 15mg d1~3,VCR 2mg d1)化疗1个疗程,加用后装治疗2球1腔、A点剂量500~600 CGy;治疗完成2周后行宫颈癌根治术,并选择20例ⅠB2~ⅡA期,直接行宫颈癌根治术患者为B组,观察肿瘤体积消退速度、术中出血情况、术后恢复情况、术后病理分析,以及术后无瘤生存率。结果 A组初查肿瘤直径>B组,治疗后肿瘤直径<B组(P<0.01);A组出血量为(250±30)ml,低于B组的(380±50)ml(P<0.01);A组脉管癌栓检出率为16.7%,低于B组的45.0%(P<0.05);宫旁及切缘癌细胞浸润数2组比较差异无统计学意义(P>0.05)。结论术前实施辅助化疗,可有效杀灭脉管内癌栓,提高放疗敏感性,加放射治疗可加快肿瘤消退速度,以利尽早手术,并增加手术彻底性,同时减少术中出血,提高无瘤生存率。
出处 《临床合理用药杂志》 2018年第11期133-134,共2页 Chinese Journal of Clinical Rational Drug Use
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