槐耳颗粒联合化学治疗在胆管癌术后辅助治疗中的临床效果

The clinical effect of Huaier granule combined with chemotherapy in postoperative adjuvant treat- ment of cholangiocarcinoma

目的探讨槐耳颗粒联合化学治疗对胆管腺癌术后患者的不良反应发生率、生活质量及生存期的影响。方法回顾性分析2015年6月至2017年6月解放军沈阳军区总医院肿瘤科收治的50例胆管腺癌根治术后辅助化学治疗患者的临床资料，按照是否联合应用槐耳颗粒分为基础治疗组与槐耳颗粒治疗组。基础治疗组22例患者，术后应用xEL0x方案，共治疗6个周期。槐耳颗粒治疗组28例患者，在XELOX方案化学治疗基础上同时口服槐耳颗粒6周。记录并比较两组患者的不良反应发生率、生活质量改善情况及无进展生存期。结果槐耳颗粒治疗组患者的白细胞减少发生率、恶心发生率低于基础治疗组，差异有统计学意义（P〈0．05）；槐耳颗粒治疗组血小板下降发生率、肝损害发生率高于基础治疗组，差异无统计学意义（P〉0．05）。槐耳颗粒治疗组患者生活质量的总改善率（60．7％）高于基础治疗组（31．8％），差异有统计学意义（P〈0．05）。槐耳颗粒治疗组患者的无进展生存期较基础治疗组显著延长。结论槐耳颗粒联合化学治疗可以降低胆管腺癌术后辅助化学治疗患者的白细胞减少及恶心发生率，改善其生活质量，延长其生存期。

Objective To investigate the effect of Huaier granule combined chemotherapy on the incidence, quality of life and survival of postoperative patients with cholangiocarcinoma. Methods A retro- spective study was performed on 50 patients with cholangiocarcinoma who were admitted from June 2015 to June 2017. According to different chemotherapy, patients were divided into the conventional treatment group （ n = 22, XELOX regimen chemotherapy for 6 weeks） and the combined treatment group （ n = 28, XELOX regimen chemotherapy combined with Huaier granule for 6 weeks）. The incidence of adverse reactions,im- provement of quality of life and progression-free survival were recorded and compared between the two groups. Results The incidence of leukopenia and nausea in the combined treatment group were lower than that in the conventional group（P 〈0. 05）. The incidence of thrombocytopenia and liver injury in the com- bined treatment group were higher than that in the conventional treatment group, and the two groups showed no statistically significant difference （P 〉 0. 05 ）. The improvement rate of QOL in the combined treatment group was（ 60. 7% ） higher than that （ 31.8% ） in the conventional group （ P 〈 0. 05 ）. The progression-free survival in the combined treatment group was significantly longer than that in the conventional treatment group. Conclusion Huaier granule combined with chemotherapy can reduce the incidence of chemothera- py-related leukopenia and nausea in the patients with cholangiocarcinoma after operation,improve the quali- ty of life of patients and prolong the survival time.