脑心通胶囊联合依达拉奉治疗老年急性脑梗死对血清炎性因子水平的影响

Clinical Effect of Naoxintong Capsules Combined with Edaravone for Treating Elderly Patients with Acute Cerebral Infarction and Its Effect on Levels of Serum Inflammatory Factors

目的探讨脑心通胶囊联合依达拉奉治疗老年急性脑梗死的疗效及对患者血清炎性因子水平的影响。方法选取医院2014年6月至2016年6月收治的老年急性脑梗死患者120例,随机分为对照组和研究组,各60例。两组患者均给予依达拉奉治疗,研究组患者加用脑心通胶囊,均连续治疗2周。结果研究组总有效率为91.67%,明显高于对照组的78.33%(P<0.05);治疗后,研究组美国国立卫生研究院卒中量表(NIHSS)评分为(5.24±1.34)分,明显低于对照组的(8.79±2.53)分(P<0.05);研究组的日常生活活动能力(ADL)评分为(72.68±8.74)分,明显高于对照组的(54.59±6.83)分(P<0.05);研究组的肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)及白细胞介素1β(IL-1β)水平分别为(14.69±4.26)μg/L,(27.46±14.52)mg/L和(13.24±1.53)ng/L,明显低于对照组的(19.73±5.24)μg/L,(38.73±15.74)mg/L和(18.26±1.32)ng/L(P<0.05);两组患者不良反应发生率相当(3.33%比5.00%,P>0.05)。结论脑心通胶囊联合依达拉奉治疗老年急性脑梗死疗效确切,可有效改善患者的神经功能和日常生活活动能力,其作用机制可能与降低血清TNF-α,IL-6和IL-1β水平有关。

Objective To investigate the clinical effect of Naoxintong Capsules combined with edaravone for treating elderly patients with acute cerebral infarction and its effect on levels of serum inflammatory factors. Results Totally 120 elderly patients with acute cerebral infarction admitted to our hospital from June 2014 to June 2016 were selected and randomly divided into the control group and the study group,60 cases in each group. The two groups were treated with edaravone,on this basis,the study group was treated with Naoxintong Capsules. The two groups were treated continuously for 2 weeks. Results The total effective rate in the study group was91. 67%,which was significantly higher than 78. 33% in the control group（ P 〈 0. 05）. After treatment,the NIHSS score in the study group was（ 5. 24 ± 1. 34） points,which was significantly lower than（ 8. 79 ± 2. 53） points in the control group（ P 〈 0. 05）. The ADL score in the study group was（ 72. 68 ± 8. 74） points,which was significantly higher than（ 54. 59 ± 6. 83） points in the control group（ P 〈 0. 05）. The levels of TNF-α,IL-6 and IL-1βin the study group were（ 14. 69 ± 4. 26） μg/L,（ 27. 46 ± 14. 52） mg/L and（ 13. 24 ± 1. 53） ng/L,which were significantly lower than（ 19. 73 ± 5. 24） μg/L,（ 38. 73 ± 15. 74） mg/L and（ 18. 26 ± 1. 32） ng/L in the control group（ P 〈 0. 05）. The incidence rate of adverse reactions was similar in the two groups（ 3. 33% vs. 5. 00%,P 〉 0. 05）.Conclusion Naoxintong Capsules combined with edaravone is effective in the treatment of elderly patients with acute cerebral infarction,it can effectively improve the nerve function and activities of daily living of the patients. The mechanism may be related to the reduction of levels of serum TNF-α,IL-6 and IL-1β.