泛发性脓疱型银屑病抗感染治疗的临床意义

Clinical Significance of Anti-infection Treatment of Generalized Pustular Psoriasis

目的分析泛发性脓疱型银屑病患者抗感染治疗的临床意义。方法回顾性分析诊断明确的42例泛发性脓疱型银屑病患者的临床资料,用SPSS 17.0软件统计处理。根据是否使用抗生素,将42例分为使用抗生素组与未使用抗生素两组。采用PASI评分评价皮损面积及严重度、疗效。比较两组患者体温恢复时间、住院时间、PASI评分、疗效。结果使用抗生素组和未使用抗生素组治疗前各指标相比,WBC、ESR及CRP差异有统计学意义(P均<0.05)。治疗后,使用抗生素组较未使用抗生素组体温恢复时间及住院时间更短、PASI评分降低更明显(P均<0.05);两组总有效率无明显差异(P>0.05)。结论合并感染的泛发性脓疱型银屑病,早期抗感染治疗有利于皮损恢复及缩短住院时间。

Objective To explore the clinical significance of anti-infection treatment of generalized pustular psoriasis（GPP）.Methods A retrospective analysis was made to the clinical data of 42 cases with confirmed diagnosis of GPP and statistical analysis was made with the software SPSS 17.0; the 42 cases were divided into 2 groups：group B（using antibiotics） and group A（using no antibiotics）; psoriasis area,severity and curative effect of the skin lesions were evaluated by psoriasis area-and-severity index（PASI score）; a comparative study on the time of body temperature recovery,time length of hospitalization,PASI scores and curative effects between the 2 groups.Results There existed a statistical difference in WBC,ESR and CRP between the 2 groups before treatment（P 〈0.05）; after treatment,the time of body temperature recovery and the time length of hospitalization were shorter and the PASI scores decreased more obviously in group B than those in group A（P〈0.05）; no obvious statistical difference in total curative effect was found between the 2 groups（P 〉0.05）.Conclusions Early anti-infection treatment of GPP combined with infection can promote the recovery of skin lesions and shorten the time length of hospitalization.