肥大细胞在肺纤维化中的作用

Role of mast cells in the pathogenesis of pulmonary fibrosis

肺纤维化是慢性进行性纤维化性间质性肺炎的终末期表现,预后差、致死率高。肥大细胞有招募、激活、分泌炎症因子,调节血管通透性,调节平滑肌细胞收缩,调节成纤维细胞生长等功能。它被认为与多种组织、器官的纤维化进程相关。在肺纤维化患者和动物模型中,均可观察到肥大细胞在肺部的增殖、激活。肥大细胞通过分泌多种生物活性物质参与肺纤维化进程。

Pulmonary fibrosis（ PF） is one kind of chronic interstitial lung disease with poor prognosis. The average survival time for most patients was less than 5 years. The functions of mast cells（ MCs） were varied,including the recruitment,activation,and differentiation of inflammatory cells,and the regulation of vascular permeability,smooth-muscle cell contractility,and fibroblast growth. It was shown that MCs were involved in the progression of fibrosis in different tissues and organs. Increasing activated MCs were observed in patients and animal models of PF.Mast cells appeared to be critical in the pathogenesis of pulmonary fibrosis by releasing a variety of cytokines.