QT间期与代谢综合征的相关性

Relationship between QT interval(QT)and metabolic syndrome

目的研究QT、QTc与代谢综合征(MS)的相关性。方法纳入2011年4月至2013年4月期间参与沈阳市城区动脉硬化及其相关疾病研究的居民,对其进行问卷调查、体格检查、实验室检查和心电图检查,依据国际糖尿病联盟(IDF)诊断标准将其分为MS组及非代谢综合征(NMS)组。QT间期由12导联心电图测得,QTc按照Bazett和Fridericia公式计算,分析QT及QTc与MS及其组分的相关性。结果共纳入739名35~64周岁居民,MS组与NMS组比较,QTcB及QTc F明显延长[(415.8±31.9)ms vs.(410.1±32.1)ms,(407.2±29.1)ms vs.(402.6±28.8)ms,P<0.05]。随着MS组成因素增多,QT、QTcB及QTc F呈延长趋势。回归分析显示QT间期与血钾、吸烟、血糖、低密度脂蛋白相关,QTc B及QTc F与患高血压病、腰围、血钾相关。结论 MS者QTc易出现延长,可能使MS患者恶性心律失常及猝死的发生风险增加,需重视对其进行心电图的检测,有助于心血管疾病的早期防治。

Objective To investigate correlation between QT interval（QT）,corrected QT interval（QTc）and metabolic syndrome（MS）. Methods Residents who participated in our survey concerning atherosclerosis andrelated diseases conducted in Shenyang were included. They accomplished questionnaire,physical examination,laboratory tests and electrocardiography test. We divided them into MS group and non-metabolic syndrome（NMS）group according to International Diabetes Federation（IDF）diagnostic criteria for MS. QT interval was mea-sured from the standard 12-lead electrocardiogram. QTc was calculated by using Bazett and Fridericia equations.We analyze correlation of QT,QTc and MS. Results A total of 739 residents who were 35 - 64 years old were in-cluded. Individuals with MS had longer QTc B and QTc F than NMS group[（415.8 ± 31.9）ms vs.（410.1 ± 32.1）ms,（407.2± 2 9.1）ms vs.（402.6 ± 28.8）ms,P〈0.05]. The more the number of abnormal MS parameters they had,the longer the QT,QTc B and QTc F they had. Regression analysis showed that QT was associated with serum potas-sium,smoking,blood glucose,and LDL,and QTc B and QTc F were associated with hypertension,waist circum-ference and blood potassium. Conclusions MS is associated with corrected QTc. Careful ECG monitoring amongpersons with MS for early detection of a long corrected QT interval may prevent severe and often fatal arrhythmiasor sudden death.