2型糖尿病患者血清胰岛素水平与心外膜脂肪组织厚度相关性分析

Correlation between serum insulin level and the thickness of epicardial adipose tissue in patients with type 2 diabetes mellitus

(1)目的探讨2型糖尿病(T2DM)患者血清胰岛素水平与心外膜脂肪组织(EAT)厚度的相关性。(2)方法选择T2DM患者101例为研究对象,测量身高、体质量,追问病史,采集空腹静脉血测量空腹血糖(FPG)、糖化血红蛋白、空腹胰岛素和C肽、甘油三酯、总胆固醇、低密度脂蛋白与高密度脂蛋白,抽餐后2小时静脉血测餐后2小时血糖、胰岛素与C肽,利用256层CT测量EAT厚度,Pearson相关性分析和Logistic多元回归分析评价EAT厚度与各变量的相关性以及相关程度。(3)结果合并有胰岛素水平升高的T2DM患者体质量指数(BMI)、甘油三酯、C肽、EAT厚度均高于胰岛素水平正常者。(4)结论 T2DM合并胰岛素水平升高者EAT厚度高于胰岛素水平正常者,且EAT厚度与BMI、甘油三酯、低密度脂蛋白、高密度脂蛋白密切相关。

Objective To explore the correlation between serum insulin level and the epicardial fatty tissue thickness in patients with type 2 diabetes mellitus.Methods Selected 101 patients with type 2 diabetes as object,measured height,weight,medical history of questioning,fasting venous blood was obtained and fasting plasma glucose,glycation hemoglobin,fasting insulin and C peptide,triglyceride（TG）,total cholesterol,low density lipoprotein（LDL）and high density lipoprotein（HDL）.Postprandial 2 hvenous blood was obtained and postprandial 2 hplasma glucose,insulin and C peptide.The thickness of the epicardial adipose tissue was measured with 256 layers of CT.Pearson correlation analysis and logistic multivariate regression analysis were used to evaluate the correlation and degree of correlation between the thickness of the fatty tissue in the pericardium and the variables.Results Patients with type 2 diabetes mellitus with elevated insulin levels,BMI,triglyceride and epicardial adipose tissue thickness were higher than those of the unconnected patients.Conclusion Patients with type 2 diabetes mellitus with elevated insulin levels,the thickness of epicardial adipose tissue is higher than those of the unconnected patients.The thickness of pericardial fatty tissue is closely related to BMI,TG,LDL and HDL.