中西医结合治疗复发性阴道假丝酵母菌病的临床疗效研究

Clinical effects of combined Chinese and Western medicine in treatment of recurrent vulvovaginal candidiasis

目的探究中药灌洗配合克霉唑片阴道纳药治疗复发性阴道假丝酵母菌病的临床疗效。方法将86例复发性阴道假丝酵母菌病患者分为两组,A组采用中药灌洗配合克霉唑片阴道纳药治疗,B组仅予克霉唑片阴道纳药治疗。对比两组临床疗效及复发率。结果治疗后,两组中医证候评分、局部体征评分及阴道分泌物检查评分均显著低于治疗前(P<0.05),且A组显著低于B组(P<0.05);A组外阴瘙痒消失时间、阴道瘙痒消失时间、阴道分泌物转阴时间、白带复常时间均显著低于B组(P<0.05);A组总有效率为95.3%,显著高于B组的81.4%(P<0.05);停药4 w后,A组复发率为7.3%,显著低于B组的37.1%(P<0.05)。结论复发性阴道假丝酵母菌病采用中药灌洗配合克霉唑片阴道纳药治疗,可显著提高临床疗效,加快恢复,减少复发。

Objective To explore the clinical effects of combined Chinese and Western medicine in the treatment of recurrent vulvovaginal candidiasis. Methods A total of 86 patients with recurrent vulvovaginal candidiasis were divided into two groups. Group A was treated with traditional Chinese medicine lavage combined with vaginal suppository Clotrimazole Tablets and group B with the latter only. The clinical effects and recurrence rate between the two groups were compared. Results After the treatment, the TCM syndrome scores, local sign scores and vaginal discharge examination scores in the two groups were significantly lower than those before the treatment(P < 0.05), and the scores in group A were significantly lower than those in group B(P < 0.05); the pruritus vulvae disappearance time, vaginal itching disappearance time, vaginal discharge clearance time and leucorrhea restoration time were significantly shorter than those in group B(P < 0.05); the overall response rate(ORR) in group A was 95.3%, which was significantly higher than the 81.4% in group B(P < 0.05). Four weeks after drug withdrawal, the recurrence rate in group A was 7.3%, which was significantly lower than the 37.1% in group B(P < 0.05). Conclusion Traditional Chinese medicine lavage combined with vaginal suppository Clotrimazole Tablets can significantly improve the clinical effects in the treatment of recurrent vulvovaginal candidiasis,accelerate recovery and reduce recurrence.