摘要
以化合物A或A'为初始原料,通过一步反应合成了17个二氢噻唑类化合物,并通过1H NMR,13C NMR和质谱对目标化合物进行了结构鉴定.生物活性测试表明,部分化合物具有较好的抑菌活性,尤其是5、5'和6对茄科劳尔氏菌和枯草芽孢杆菌都显示出较高的抑菌活性,且比青霉素钠抑菌活性更高.
Seventeen novel dihydrothiazole derivatives were synthesized from compounds A and A＇ in one step.The structures of the compounds were characterized by IR,1 H-NMR,13 C-NMR,and MS analysis. The bioassay showed that some of the synthesized dihydrothiazole derivatives exhibited excellent antibacterial activities.Especially,compounds 5,5＇ and 6 exhibited much higher activities against bacillus subtilis and staphylococcus aureus than penicillin.
作者
郑绍军
杨丹丹
朱瑞
谭芳芳
张继文
ZHENG Shaojun;YANG Dandan;ZHU Rui;TAN Fangfang;ZHANG Jiwen(School of Enviromnental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, China;Marine Equipment and Technology Institute, Jiangsu university of Scince and Technology, Zhenjiang 212003, China;College of Chemistry ＆ Pharmacy, Northwest A＆F University, Yangling 712100, China)
出处
《江苏科技大学学报（自然科学版）》
CAS
2018年第2期277-284,共8页
Journal of Jiangsu University of Science and Technology:Natural Science Edition
基金
国家自然科学基金资助项目(21502073)
江苏省自然科学基金资助项目(BK20150465)
江苏高校(高技术船舶)协同创新中心及江苏科技大学海洋装备研究院资助项目(HZ2016012)
关键词
二氢噻唑类化合物
抑菌活性
合成
dihydrothlazoles derivatives
antibacterial activities
synthesis
