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中青年急性脑梗死与尿酸、糖脂代谢指标的相关性研究 被引量:2

Correlational study of uric acid,glyco-lipid metabolism and acute cerebral infarction in young and middle-aged patients
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摘要 目的探讨尿酸、糖脂代谢指标与中青年急性脑梗死的关系。方法选取中青年急性脑梗死患者118例为脑梗死组,选取同期的健康体检者118例为对照组,比较两组空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)、血尿酸(UA)、同型半胱氨酸(HCY)水平,分析它们与中青年急性脑梗死的关系。结果脑梗死组TG水平为(2.16±0.74)mmol/L,高于对照组TG水平(1.65±0.64)mmol/L;脑梗死组LDL-C水平为(3.72±1.21)mmol/L,高于对照组LDL-C水平(2.73±0.67)mmol/L;脑梗死组HCY水平为(18.08±5.66)μmol/L,高于对照组HCY水平(13.03±3.59)μmol/L;差异有高度统计学意义(P均<0.01)。脑梗死组TC水平为(5.23±1.19)mmol/L,高于对照组TC水平(4.87±1.26)mmol/L,差异有统计学意义(P<0.05);脑梗死组UA水平为(357.84±85.62)μmol/L,高于对照组UA水平(334.78±67.20)μmol/L,差异有统计学意义(P<0.05)。两组FPG、Logistic多因素回归分析结果显示,TC、TG、HCY、UA分别是中青年急性脑梗死的独立危险因素(P<0.05)。结论中青年急性脑梗死患者的危险因素较多,控制并减少危险因素,尤其是降血脂,降尿酸,纠正高HCY,对中青年急性脑梗死的防治十分重要。 Objective To explore the relationship between the level of uric acid, glyco-lipid metabolism and acutecerebral infarction in young and middle-aged patients.Methods 118 young and middle-aged patients with acute cere-bral infarction and 118 healthy people were divided into the cerebral infarction group and the control group respective-ly.The fasting serum glucose (FPG), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C), highdensity lipoprotein (HDL-C), uric acid(UA) and homocysteine(HCY) of the two groups were compared.Results Thelevel of TG of the cerebral infarction group (2.16±0.74)mmol/L was higher than that of the control group (1.65±0.64)mmol/L.The level of LDL-C of the cerebral infarction group (3.72±1.21)mmol/L was higher than that of thecontrol group (2.73±0.67)mmol/L.The level of HCY of the cerebral infarction group (18.08 ±5.66)μ mol/L washigher than that of the control group (13.03±3.59)μ mol/L.There was statistically significant difference( 〈0.01).The level of TC of the cerebral infarction group (5.23 ±1.19)mmol/L was higher than that of the control group(4.87±1.26)mmol/L and the difference was statistically significant( 〈0.05).The level of UA of the cerebral infarc-tion group(357.84±85.62)μ mol/L was higher than that of the control group(334.78±67.20)μ mol/L and the differ-ence was statistically significant( 〈0.05). regression analysis showed that TC, TG, HCY and UA were riskfactors for acute cerebral infarction in young and middle-aged patients( 〈0.05).Conclusion There are many riskfactors regarding cerebral infarction in young and middle-aged patients. It is important to prevent and control cerebralinfarction in young and middle-aged patients by controlling and reducing risk factors, especially lowering blood lipids,lower uric acid and correcting high HCY.
出处 《中国疗养医学》 2018年第5期451-453,共3页 Chinese Journal of Convalescent Medicine
关键词 脑梗死 中青年 尿酸 糖脂代谢 Cerebral infarction Young and middle-aged Uric acid Glyco-lipid metabolism
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