综合干预对痰湿体质的轻中度非酒精性单纯性脂肪肝疗效观察

Effect observation of comprehensive intervention on NAFLD patients of phlegm dampness constitution

目的探索综合干预对轻中度非酒精性单纯性脂肪肝患者BMI、血脂检查、B超等指标变化的疗效观察。方法采用横断面调查方法。在调查对象获得知情同意的基础上,对符合轻中度非酒精性单纯性脂肪肝(N AFLD)诊断标准的患者进行中医体质测试,对符合痰湿体质患者随机分为实验组(48例)和对照组(45例)。两组均予多烯磷脂酰胆碱胶囊规范化治疗,但对照组延续原有的生活方式,实验组予健康护理干预,3个月后观察比较两组患者治疗前后体重指数、血脂检查、B超等指标变化情况。结果实验组患者脂肪肝的程度均减轻或治愈,护理后BMI(23.61±2.35)kg/m^2、体质积分(73.26±5.58)分较治疗前(27.21±1.33)kg/m^2、(78.25±8.58)分显著改善或转为正常(P<0.05),但对照组无明显改善(P>0.05),两组护理后差异有统计学意义(P<0.05);实验组TG、TC、LDL较对照组降低,HDL较对照组升高(均P<0.05);3个月后实验组总有效率高于对照组(P<0.05)。结论综合干预可以有效改善痰湿体质N ALFD患者的临床症状、体征,改善患者体重指数、血脂水平,具有良好的保肝、降脂、减轻体质量的作用,对降低NALFD的发病率,提高NALFD现患人群的逆转率具有重要意义。

Objective Clinical observation was conducted to explore the effect of comprehensive intervention onBMI, blood lipid examination and b-ultrasound on patients with mild and moderate nonalcoholic fatty liver disease.Methods A cross-sectional survey was used.With the consent of subjects, physical fitness test was given to patientswith mild and moderate nonalcoholic fatty liver disease （NAFLD）.The patients of phlegm dampness constitution weredivided into the experimental group（48 cases） and the control group （45 cases）.The two groups were given standard-ized treatment of polyene phosphatidylcholine capsules.The control group continued their former way of life while theexperimental group was given health care intervention.3 months later, the BMI, results of B ultrasonic examinationand blood lipid of patients before and after the treatment were observed and compared.Results The fatty liver of pa-tients in the experimental group was improved or cured.After the treatment, the BMI of the experimental group was（23.61±2.35）kg/m2and the constitution score was（73.26±5.58）, significantly higher than those of（27.21±1.33）kg/m2and（78.25±8.58） before the treatment（ 〈0.05）.The control group had no obvious improvement（ 〉0.05）.The dif-ference of the two groups showed significant differences（ 〈0.05）.TG, TC and LDL of the experimental group lowercompared with those of the control group while HDL increased（ 〈0.05）.3 months later, the total effective rate ofthe experimental group was higher than that of the control group（ 〈0.05）.Conclusion Comprehensive interventioncan effectively improve the clinical symptoms, signs of NALFD patients with phlegm dampness constitution and im-prove the body mass index and blood lipid levels of patients. It enjoys a good effect of liver-protection, fat-reductionand weight loss. It can also lower the incidence of NALFD and is of great significance in improving the reverse rateof NALFD patients.