浅析甘精胰岛素联合瑞格列奈治疗2型糖尿病的临床效果

Evaluation of Clinical Effect of Insulin Glargine Combined with Repaglinide in the Treatment of Type 2 Diabetes Mellitus

目的:分析研究甘精胰岛素加入瑞格列奈进行治疗的临床效果。方法:利用随机数字表法,将56例入院接受2型糖尿病治疗的患者均分为两组,观察组28例,给予甘精胰岛素液加上瑞格列奈的治疗;对照组28例,给予精蛋白生物合成人胰岛素注射液(诺和灵30R)。记录两组患者的治疗总有效率、空腹时血糖数值、糖化血红蛋白数值及不良症状发生率。结果:接受治疗后,观察组治疗总有效率(96.43%)显著高于对照组(75.00%),差异有统计学意义(P<0.05);观察组的空腹血糖数值(6.5±1.2)mmol/L,明显比对照组的(7.7±1.4)mmol/L少,差异有统计学意义(P<0.05);观察组糖化血红蛋白(6.4±1.1)%,显著低于对照组的(7.5±1.2)%,差异有统计学意义(P<0.05);观察组的不良症状发生率(3.57%)也显著少于对照组(21.43%),差异有统计学意义(P<0.05)。结论:采用甘精胰岛素与瑞格列奈的结合能有效改善2型糖尿病患者的身体状况,高效控制血糖水平和糖化血红蛋白的数值,降低不良症状的发生率,具有较显著的临床作用,值得推广。

Objective：To analyze and study the clinical effects of Insulin Glargine combined with Repaglinide in the treatment of type 2 diabetes mellitus.Method：56 cases with type 2 diabetes mellitus and who admitted in our hospital were divided into two groups by the random number table method.The observation group of 28 cases were treated with Insulin Glargine combined with Repaglinide solution,while the control group of 28 cases were given Isophane Protamine Biosynthetic Human Insulin Injection（Novolin 30 R）.Then,the total effective rate,fasting blood glucose value,glycosylated hemoglobin value and adverse symptom rate of two groups of patients were recorded.Result：After treatment,the total effective rate in the observation group was 96.43%,which was significantly higher than 75.0% of the control group（P〈0.05）.The fasting blood glucose value in the observation group was（6.5±1.2）mmol/L,which was significantly less than（7.7±1.4）mmol/L in the control group（P〈0.05）.The glycosylated hemoglobin in the observation group was（6.4±1.1）%,which was significantly lower than（7.5±1.2）% in the control group（P〈0.05）.The incidence of adverse symptoms in the observation group was 3.57%,which was also significantly less than 21.43% in the control group（P〈0.05）.Conclusion：The Insulin Glargine combined with Repaglinide which can effectively improve the physical condition of patients with type 2 diabetes mellitus,effectively control the blood sugar level and the value of glycosylated hemoglobin,and reduce the incidence of bad symptoms,thus it has more prominent clinical effect and it is worthy to be promoted.