2600例孕妇血清甲状腺功能检测结果分析及甲状腺指标变化的意义

Analysis of Serum Thyroid Function Test and the Significance of Thyroid Index Changes in 2600 Cases of Pregnant Women

目的:观察不同孕期、不同年龄孕妇血清甲状腺指标变化,为临床干预提供指导。方法:选取笔者所在医院产科建卡,接受产前检查的孕妇2 600例作为研究对象,根据孕期分成三组,早期组(n=925)、中期组(n=855)、晚期组(n=820),选取同期体检非妊娠女性健康者800例作为对照组,分别进行血清甲状腺功能检测,比较各组血清甲状腺功能相关指标。结果:四组间FT4、FT3、T4、T3、TSH水平比较,差异均有统计学意义(P<0.05)。不同年龄段孕妇FT4、T4、TSH水平比较,差异均有统计学意义(P<0.05)。结论:孕妇血清甲状腺指标与非妊娠女性存在差异,且不同孕期、不同年龄孕妇血清甲状腺指标存在差异,特别是高龄孕妇容易出现甲状腺功能减退,应加强监测,发现异常及时干预可减少不良妊娠。

Objective：To observe the changes of serum thyroid indexes in pregnant and different pregnant women in different stages of pregnancy and to provide guidance for clinical intervention.Method：In our hospital Gynaecology and Obstetrics,prenatal examination of pregnant women in 2 600 cases were selected as the research object,they were divided into 3 groups according to pregnancy,early group（n=925）,middle group（n=855） and late group（n=820）,non pregnant women＇s health examination were selected as a control group of 800 cases,respectively,serum thyroid function tests,serum thyroid function related indicators were compared.Result：The differences of FT4,FT3,T4,T3 and TSH between the 4 groups were statistically significant（P〈0.05）.The differences of FT4,T4 and TSH in different age groups of pregnant women were statistically significant（P〈0.05）.Conclusion：The serum thyroid index of pregnant women and non pregnant women are different,and different period and different age of pregnant women serum thyroid index differences,especially the elderly pregnant women prone to hypothyroidism,shall strengthen the monitoring, abnormal timely intervention can reduce adverse pregnancy.