围绝经期晚期乳腺癌卵巢功能检测与内分泌治疗相关性临床评价

Clinical evaluation of ovarian function detection and endocrine therapy for advanced perimenopausal breast cancer

目的探讨围绝经期晚期乳腺癌卵巢功能检测与内分泌治疗相关性。方法选取我院2013年1月~2015年9月围绝经期乳腺癌患者88例。通过卵巢功能检测,给予患者针对性治疗。观察患者的疗效、毒副反应及生存期。结果绝经后阿那曲唑组与绝经前药物去势组,分别与绝经后三苯氧胺组和绝经前三苯氧胺组的总有效率存在显著性差异(P<0.05);绝经后三苯氧胺组总有效率,优于绝经前三苯氧胺组,但无显著性差异(P>0.05)。结论围绝经期晚期乳腺癌患者,特别是无法耐受全身化疗的患者,通过测定E2与FSH水平后,为患者实施有效地内分泌治疗措施,能够延长患者的生存期,提升患者的生存质量。

Objective To investigate the correlation between ovarian function and endocrine therapy in patients with advanced stage of perimenopausal period.Methods A total of 88 patients with perimenopausal breast cancer from January 2013 to September 2015 in our hospital were selected. Through the ovarian function test, give patients targeted treatment.Observe the clinical effect, side effects and survival of patients.Results The total effective rate of anastrozole group and premenopausal group was significantly different from that of menopausal tamoxifen group and premenopausal tamoxifen group（P〈 0.05）. The total effective rate of menopausal tamoxifen group was significantly higher than that of menopausal tamoxifen group In the premenopausal tamoxifen group, but no significant difference（P 〉0.05）.Conclusion In patients with advanced perimenopausal women with breast cancer, especially those who can not tolerate systemic chemotherapy,effective measures for endocrine therapy can be obtained by measuring the levels of E2 and FSH, prolonging survival and improving patients＇ quality of life.