曲克芦丁脑蛋白水解物注射液联合养血清脑颗粒对急性脑梗死患者NIHSS评分及生活质量的影响

Effect of Troxerutin Protein Hydrolysates Combined with Yangxue Qingnao Granule on NIHSS Score and Quality of Life in Patients with Acute Cerebral Infarction

目的:研究曲克芦丁脑蛋白水解物注射液联合养血清脑颗粒对急性脑梗死(ACI)患者神经功能缺损(NIHSS)评分及生活质量的影响。方法:选取焦作市第二人民医院收治的ACI患者82例,依照治疗方案不同分为研究组(n=41)与对照组(n=41),对照组采用常规对症治疗,研究组于对照组基础上采用曲克芦丁脑蛋白水解物注射液+养血清脑颗粒治疗。观察比较两组治疗效果、治疗前后NIHSS评分、血液流变学指标(血浆黏度、血小板聚集率、红细胞压积)及生活质量变化情况。结果:研究组治疗总有效率97.56%(40/41)高于对照组80.49%(33/41),差异有统计学意义(P<0.05);治疗后研究组NIHSS评分低于对照组,差异有统计学意义(P<0.05);治疗后研究组血浆黏度、血小板聚集率、红细胞压积低于对照组,差异有统计学意义(P<0.05);治疗后研究组生活质量(WHOQOL-100)评分高于对照组,差异有统计学意义(P<0.05)。结论:曲克芦丁脑蛋白水解物注射液联合养血清脑颗粒治疗ACI能显著提高治疗效果,降低患者NIHSS评分,改善患者神经功能,保持血液流变学稳定,提高患者生活质量。

Objective： To investigate the effect of Troxerutin protein hydrolysates combined with Yangxue Qingnao Granule on nerve function defect（NIHSS） score and quality of life in patients with acute cerebral infarction（ACI）. Methods： A total of 82 cases of ACI patients in our hospital were selected and divided into study group（n=41） and control group（n=41） according to the different treatment. The control group was treated with conventional symptomatic treatment, and the study group was treated with Troxerutin protein hydrolysates combined with Yangxue Qingnao Granule on the basis of the control group. The therapeutic effect, NIHSS score, hemorheology indexes（plasma viscosity, platelet aggregation rate, hematocrit） and quality of life in two groups were observed and compared. Results： The total effective rate of the study group was 97.56%（40/41）, which was higher than that of the control group 80.49%（33/41）, and the difference was statistically significant（P〈0.05）. After treatment, the NIHSS score of the study group was significantly lower than that of the control group（P〈0.05）. After treatment, plasma viscosity, platelet aggregation rate and hematocrit in the study group were lower than those in the control group（P〈0.05）. After treatment, the quality of life（WHOQOL-100） score in the study group was higher than that in the control group（P〈0.05）. Conclusion： Troxerutin protein hydrolysates combined with Yangxue Qingnao Granule on nerve function defect（NIHSS） score and quality of life in patients with ACI can significantly improve the effect of treatment, reduce the NIHSS score, improve the neurological function, keep the blood rheology stable and improve the quality of life of the patients.