髓芯减压配合鹿龟生骨丸治疗早期股骨头坏死临床观察

Clinical effect of core decompression with Luguishenggu pills on early femoral head necrosis

目的:探讨髓芯减压配合鹿龟生骨丸治疗早期股骨头坏死临床疗效。方法:选取74例早期股骨头坏死患者,随机分为对照组与治疗组各37例。对照组实施髓芯减压术治疗,治疗组采用髓芯减压术配合鹿龟生骨丸治疗,疗程6个月。疗程结束后,统计两组临床疗效,并对比治疗前后两组疼痛评分(VAS)及髋关节功能评分(Harris)以及炎性因子:超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)水平变化情况。结果:治疗组总有效率97.30%,明显高于对照组的78.38%,差异有统计学意义(P<0.05);治疗组VAS评分和Harris评分,hs-CRP、TNF-α、IL-1β值明显优于对照组,差异均有统计学意义(P<0.05)。结论髓芯减压配合鹿龟生骨丸治疗早期股骨头坏死疗效确切,可有效降低炎性因子表达水平,缓解患者疼痛感,改善髋关节功能,提高治疗效果。

Objective： To explore the clinical effect of core decompression with Luguishenggu pills on early femoral head necrosis. Methods： 74 cases of selected patients with early femoral head necrosis were divided randomly into control group（ n = 37） and treatment group（ n = 37）. The control group was treated with core decompression,while the treatment group was treated with core decompression combined with Luguishenggu pills. The course of treatment was 6 months. After course of treatment,we analyzed the clinical effects of two groups statistically,and compared the pain scores（ VAS） and hip joint function score（ Harris） as well as the change of level of inflammatory factors（ incliding： ultra sensitive C-reactive protein（ hs-CRP）,tumor necrosis factor-α（ TNF-α）,interleukin-1β（ IL-1β） before and after treatment in two groups. Results： The total effective rate of treatment group was97. 30%,significantly higher than 78. 38% of control group,and the difference was statistically significant（ P〈0. 05）. VAS score and Harris score as well as values of hs-CRP,TNF-α and IL-1β of treatment group were significantly better than those of control group,and the difference was statistically significant（ P〈0. 05）. Conclusion： The clinical effect of core decompression with Luguishenggu pills on early femoral head necrosis is definite,which can reduce the level of expression of inflammatory factors effectively,ease the pain perception of patients,improve the hip joint function,and enhance the effect of treatment.