中国2013-2015年<15岁儿童吉兰-巴雷综合征流行特征与时空聚集性

Epidemiological characteristics and temporal-spatial clusters of Guillain-Barré syndrome among children under 15 years old in China,2013-2015

目的了解中国（未包括中国香港特别行政区、澳门特别行政区和台湾）2013-2015年〈15岁儿童吉兰-巴雷综合征（Guillain-Barrésyndrome,GBS）流行特征及空间聚集性。方法采用描述流行病学方法分析2013-2015年〈15岁儿童通过急性弛缓性麻痹病例监测信息报告管理系统报告的GBS病例数据,使用时空聚集性探索方法分析GBS可能的聚集区域。结果 2013-2015年中国共报告GBS 2 803例,报告发病率为0.41/10万（标化：0.42/10万）;男、女性报告发病率分别为0.47/10万、0.35/10万;春季、秋季和冬季报告病例分别占22.51%、26.26%和26.51%;GBS病例存在4个时空聚集的县级区域。结论中国2013-2015年GBS发病存在时空聚集性。

Objective To determine the epidemiological characteristics of Guillain-Barr6 syndrome （GBS） among children under 15 years old, and to identify temporal-spatial clusters of GBS in China （excluding Chinese Hong Kong Special Administrative Region, Macao Special Administrative Region, and Taiwan）, 2013-2015. Methods Descriptive methods were used to analyze GBS cases 〈 15 years old in 2013-2015. A retrospective, temporal-spatial analysis was used to detect possible clusters in China. Results A total of 2 803 GBS case- were reported, for an incidence of 0. 41 per 100 000 population （ adjusted： 0. 42 per 100 000 population）. The incidence of GBS was 0. 47 per 100 000 population among males and 0. 35 per 100 000 population among females; 22. 51%, 26. 26% and 26. 51% of GBS cases occurred in spring, autumn and winter, respectively. County-level temporal-spatial clusters of GBS were detected in 4 areas. Conclusions GBS showed temporal-spatial clustering in China during 2013-2015.