半乳糖凝集素4在非小细胞肺癌组织中的表达及意义

Expression of galectin-4 in non-small cell lung cancer and its clinical significance

目的探讨半乳糖凝集素4(Gal-4)在非小细胞肺癌(NSCLC)组织中的表达及临床意义。方法选取100例NSCLC患者,经手术切除的100例癌组织作为观察组,取相应的癌旁正常肺组织作为对照组。采用免疫组织化学染色法检测Gal-4在两种组织中的表达情况,并分析其表达与患者性别、年龄、吸烟、组织学类型、肿瘤大小、淋巴结转移、远处转移等临床病理特征的关系。结果 Gal-4在NSCLC癌组织中的表达率(48.00%)明显高于癌旁正常肺组织(0),差异有统计学意义(P<0.05)。Gal-4在肺腺癌中的表达率(84.44%)明显高于肺鳞癌(22.22%)及大细胞肺癌(0),Gal-4在有淋巴结转移的NSCLC中表达率(61.22%)明显高于无淋巴结转移的NSCLC(35.29%),差异有统计学意义(P<0.05)。Gal-4的表达与肺腺癌的淋巴结转移相关(P<0.05),与肺鳞癌淋巴结转移无关(P>0.05),与患者的性别、年龄、吸烟、肿瘤大小、远处转移等均无关(P>0.05)。结论 Gal-4在NSCLC的肺腺癌中表达率最高,对预测肺腺癌淋巴结转移有重要临床意义。

Objective To investigate the expression and clinical significance of galectin- 4 （Gal -4） in non - small cell lung cancer （NSCLC）. Methods A hundred eases of NSCLC patients were selected. The experimental group was consisted with 100 cases cancer tissue by surgical resection, and control group comes from the corresponding adjacent normal lung tissues. The expression of Gal - 4 in both groups was examined by the immunohistochemical staining method. The correlations between the expression of Gad -4 and clinicopathological features, such as gender, age, smoking, histo- logical type, tumor size, lymph node metastasis and distant metastasis were analyzed. Results The positive expression rate of Gal -4 in cancer tissue （48. 00% ） was significantly higher than that in adjacent normal lung tissue （0. 00% ） （P 〈 0. 05 ）. The positive expression rate of Gal -4 in lung adenoeareinoma （84. 440/0 ） was significantly higher than that in lung squamous cell carcinoma （22. 22% ） and large cell lung cancer （0. 00670 ）. The positive expression rate of Gal- 4 with lymph node metastasis （61.22%） was significantly higher than that without lymph node metastasis （35.29%） in NSCLC （ P 〈 0.05 ）. The expression of Gal - 4 was significantly correlated with the lymph node metastasis in lung adeno- carcinoma （ P 〈 0. 05 ）, but not in lung squamous cell carcinoma （ P 〉 0. 05 ）. The expression of Gal - 4 is not correlated with the gender, age, smoking, tumor size and distant metastasis （P 〉 0. 05 ）. Conclusion Gal - 4 has the highest ex- pression rate in lung adenocareinoma of NSCLC and has important clinical significance in predicting lymph node metastasis in lung adenocareinoma.