摘要
目的:探讨疏风解毒胶囊治疗上气道咳嗽综合征(UACS)的临床疗效和安全性。方法:有基础鼻或鼻窦疾患的UACS患者55例随机分成观察组(n=28)和对照组(n=27)。对照组予氯雷他定片10 mg qd;布地奈德鼻喷剂128μg,喷鼻,bid;罗红霉素分散片0.15 g qd。观察组在对照组基础上加用疏风解毒胶囊40 mg·kg^(-1),po,tid。两组均连续用药4周。观察两组患者治疗前后各项症状积分变化及药品不良反应,评价两组疗效。结果:观察组总有效率达85.71%,明显优于对照组的70.37%(P<0.05)。两组患者鼻部症状和咳嗽症状均较治疗前明显改善(P<0.05),且观察组各项症状积分均优于对照组(P<0.05)。结论:常规治疗方案加用疏风解毒胶囊治疗UACS能明显提高临床疗效。
Objective: To observe the clinical effect of Shufeng Jiedu capsules combined with the conventional treatment on upper airway cough syndrome (UACS). Methods: Totally 55 patients with UACS and basic nasal or sinus diseases were randomly divided into two groups: the treatment group (n = 28) and the control group (n = 27). The treatment group was treated with Shufeng Jiedu capsules combined with the regimen for the control group, 40 mg · kg-1 , 3 times a day, and the regimen for the control group was as follows: loratadine tablets, 10 mg,qd, budesonide nasal spray hormone 128 μg, bid, roxithromycin dispersible tablets, 0.15 g,qd. The treatment course was 4 weeks. The changes of symptom scores were observed and the adverse reactions were recorded to compare the efficacy between the groups. Results: The total effective rate of the treatment group was 85.71%, which was significantly higher than that of the control group (75.37%, P 〈 0.05). The cough and nasal symptoms were notably improved in the two groups after the treatment(P 〈 0.05 ), and all the symptom scores in the treatment group were better than those in the control group (P 〈 0.05). Conclusion: Shufeng Jiedu capsules combined with the conventional treatment can improve the efficacy in the treatment of UACS.
作者
吴启富
赵将
吴江华
Wu Qifu;Zhao Jiang;Wu Jianghua(Huaying Maternal and Child Health Hospital, Sichuan Huaying 638699, China;Department of Pediatrics, Mianyang People's Hospital)
出处
《中国药师》
CAS
2018年第5期856-858,共3页
China Pharmacist
关键词
疏风解毒胶囊
上气道咳嗽综合征
慢性咳嗽
疗效
Shufeng Jiedu capsules
Upper airway cough syndrome
Chronic cough
Curative effect