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分子生物学在年龄推断中的研究进展 被引量:2

Research progress of molecular biology in age estimation
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摘要 年龄推断是法医学研究与实践的重点和难点内容之一。目前,年龄推断主要依据骨龄、牙龄等形态学方法,但误差较大、影响因素较多。近年来,随着分子生物学理论与技术的发展,研究者发现某些细胞分子水平与年龄密切相关。本文就目前细胞分子水平与年龄关系的研究进展进行综述。 Age estimation was one of the important and difficult con}ents in forensic medicine research and practice. Age estimation was mainly based on bone age and dental age in present. However, the errors were large, and it was influenced by other factors. In recent years, following with the development of molecular biology theories and techniques, researchers have found that some cellular and molecular levels were related to age. In this review, the research progress of molecular biology in age estimation was reviewed.
作者 袁超群 王妹 邓小冬 Yuan Chaoqun;Wang Mei;Deng Xiaodong(Department of Forensic Medicine, North Sichuan Medical College, Nanchong, Sichuan 637000, Chin)
出处 《中国法医学杂志》 CSCD 2018年第2期139-141,145,共4页 Chinese Journal of Forensic Medicine
基金 四川省教育厅科研基金重点项目(16ZB0235 14ZA0191) 川北医学院科研发展计划项目(CBY15-A-YB19)
关键词 法医人类学 年龄推断 分子生物学 分子水平 forensic anthropology, age estimation, molecular biology, molecular level
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  • 1徐晓玲,郑卫平,黄君键.线粒体DNA和端粒与年龄相关性的研究进展[J].中国法医学杂志,2005,20(6):347-349. 被引量:1
  • 2李成涛,李莉,柳燕.血细胞线粒体DNA 4977缺失与年龄的相关性[J].法医学杂志,2006,22(5):346-348. 被引量:1
  • 3Arnheim N, Cortopassi G. Deleterious mitochondrial DNA mutations accumulate in aging human tissues [J]. Mutat Res, 1992, 275(3-6):157-167.
  • 4Hsieh RH, Hou JH, Hsu HS, et al. Age-dependent respiratory function decline and DNA deletions in human muscle mitochondria [J]. Biochem Mol Biol Int, 1994, 32(6):1009-1022.
  • 5Meissner C, yon Wurmb N, Oehmichen M. Detection of the age-dependent 4977 bp deletion of mitochondrial DNA. A pilot study[J]. Int J Legal Med, 1997, 110(5): 288-291.
  • 6Anderson S, Bankier AT, Barrel BG, et al. Sequence and organization of the human mitochondrial genome[J]. Nature, 1981, 290(5806):457-464.
  • 7Fliss MS, Usadel H, Caballero Oil, et al. Facile detection of mitochondrial DNA mutations in tumors and bodily fluids[J]. Science, 2000, 287(5460):2017-2019.
  • 8Yen TC, Pang CY, Hsieh RH, et al. Age-dependent 6kb deletion in human liver mitochondrial DNA [J]. Biochem Int, 1992, 26(3):457-468.
  • 9Wei YH. Mitochondrial DNA alterations as ageing-associated molecular events [J]. Mutat Res, 1992, 275(3- 6):145-155.
  • 10Lai LP, Tsai CC, Su MJ, et al. Atrial fibrillation is associated with accumulation of aging-related common type mitochondrial DNA deletion mutation in human atrial tissue [J]. Chest, 2003, 123(2):539-544.

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