摘要
目的分析河南部分地区艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人(简称HIV/AIDS病人)合并感染丙型肝炎病毒(HCV)的流行现状及特点。方法采取横断面调查,对郑州市和驻马店新蔡县HIV/AIDS病人开展HCV抗体检查,随机抽取40%的HIV合并HCV感染者进行HCV病毒载量检测。结果 2 395例HIV/AIDS病人中,男性1 573例,女性822例,平均年龄(45±13)岁。新蔡县HIV/AIDS病人以农民为主,占82.93%,HIV感染途径以血液传播为主,占75.47%;郑州市HIV/AIDS病人以自由职业者(47.04%)和职员(40.41%)为主,感染途径以性传播为主,占79.17%。HIV/AIDS病人合并HCV感染率为29.31%(702/2 395),其中新蔡县合并HCV感染率为51.48%高于郑州市的10.06%(χ~2=493.31,P〈0.05),血液传播和母婴传播HIV合并HCV感染率高于性传播(χ~2=554.63,P〈0.05)。对265例HIV合并HCV感染者进行HCV病毒载量检测,HCV-核糖核酸(RNA)检出率为51.70%(137/265),其中新蔡县HCV-RNA检出率为55.17%,郑州市为27.27%,两者差异有统计学意义(χ~2=9.006,P〈0.05)。郑州市患者HCV-RNA检测值为(5.33lg±1.12lg),新蔡县为(5.91lg±1.27lg),两者差异无统计学意义(T=1.417,P〉0.05)。结论河南部分地区HIV/AIDS病人中有较高的HCV感染率,农村高于城市,血液传播高于性传播,HCV-RNA检出率农村高于城市,应加强农村地区HIV/AIDS病人合并HCV感染状况的检测。
Objective To investigate the prevalence of HIV/AIDS and HCV co-infection in part of Henan province.Methods A cross-sectional survey was carried out among HIV/AIDS patients with HCV antibody screening in Zhengzhou city(urban areas)and Xincai county(rural areas),and 40% of HIV/HCV co-infected persons were randomly selected for hepatitis C virus load.Results Of 2395 HIV/AIDS patients,there were 1573 males and 822 females with an average age of 45±13 years.82.93%of the HIV/AIDS patients in Xincai were farmers and 75.47%infected with HIV through blood transmission,and in Zhengzhou 87.45% were self-employed and office clerk,and 79.17%infected with sexual transmission.The rate of HIV/HCV co-infection was 29.31%(702/2395),with those in Xincai(51.48%)significantly higher than those in Zhengzhou(χ~2=493.31,P0.05).The rate of HCV infection through blood and mother to child transmission was higher than that through sexual transmission(χ~2=554.63,P0.05).265 HIV/HCV co-infected patients were detected by HCV virus load,with the detection rate of HCV-RNA 51.69%(137/265).The detection rate of HCV-RNA in Xincai was higher than that in Zhengzhou(χ~2=9.006,P0.05).HCV-RNA detection value of the patients was 5.33 lg±1.12 lg in Zhengzhou and 5.91 lg±1.27 lg in Xincai,with the difference not so significant.Conclusion There is a higher HCV co-infection rate among HIV/AIDS patients in some areas of Henan province,and the rate in the rural area is higher than that in the urban area.Blood transmission is higher than sexual transmission.The detection rate of HCV-RNA in the rural area is higher than that in the urban area.The detection of HCV co-infection should be strengthened among HIV/AIDS patients esp.in rural areas.
作者
陈昭云
孙燕
马淑焕
赵清霞
张丽
张向前
徐丽霞
CHEN Zhaoyun;SUN Yah;MA Shuhuan;ZHAO Qingxia;ZHANG Li;ZHANG Xiangqian;XU Lixia(The Sixth People's Hospital of Zhengzhou, Henan Zhengzhou 450015 ,China;Center for Disease Control of Xincai County)
出处
《中国艾滋病性病》
CAS
CSCD
北大核心
2018年第4期334-336,共3页
Chinese Journal of Aids & STD
基金
2016年度河南省医学科技攻关计划项目,(201602342)
“十二五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2012ZX10004905-003-001)~~