青年乳腺癌钼靶X线表现与其分子分型的关系

Relationship between X-ray features of mammography and molecular phenotypes of young patients with breast cancer

目的探讨青年乳腺癌患者的钼靶X线表现与其分子分型间的关系。方法回顾性分析2012年1月至2017年5月在陕西省人民医院145例经手术后病理证实为原发性乳腺癌青年患者的钼靶X线影像及病理资料,分析钼靶X线表现与免疫组化分子分型间的关系。结果青年乳腺癌免疫组化分子分型最常见为Luminal B型(58/145,40.00%),其次分别为三阴性(32/145,22.06%)、人类表皮生长因子受体2(HER-2)过表达型(29/145,20.00%)和Luminal A型(26/145,17.94%)。Luminal B型乳腺癌最常见的X线表现为肿块伴钙化(28/58,48.28%)(χ~2=23.997,P<0.01),钙化X线特征多表现为线样及节段样分布(17/33,51.52%)(χ~2=13.165,P<0.01)。三阴性乳腺癌最常见的X线表现为边缘光滑(18/26,69.23%)(χ~2=26.247,P<0.01)的单纯肿块(25/32,78.13%)(χ~2=33.617,P<0.01),肿块直径多>5cm(16/26,61.54%)(χ~2=10.664,P<0.05)。HER-2过表达型最常见的X表现为单纯钙化(16/29,55.17%)(χ~2=25.948,P<0.01),钙化X线特征多表现为簇状钙化(13/22,59.09%)(χ~2=17.803,P<0.01)。Luminal A型乳腺癌最常见的X表现为边缘毛刺征的肿块(9/15,60.00%)(χ~2=21.234,P<0.01)。结论青年乳腺癌的X线表现与分子分型间有一定的关系,能为判断肿瘤生物学行为及患者预后提供一定的参考价值。

Objective To study the relationship between the X-Ray features of mammography and molecular phenotypes of young patients with breast cancer. Methods The mammography features and pathological data of 145 young patients with primary breast cancer diagnosed by postoperative pathology examination were analyzed retrospectively to analyze the relationship between X-Ray features of mammography and immunohistochemistry molecular phenotypes. Results The most common type of immunohistochemistry molecular phenotypes was Luminal B （58/145, 40.00%）, followed by triple negative （32/145, 22.06%）, HER-2 overexpression type （29/145, 20.00%） and Luminal A （26/145, 17.94%）. The most common mammography features of Luminal B breast cancer was mass with calcification （28/58, 48.28%） （χ^2= 23.997, P 〈0.01 ）, and calcification characteristics was linear and segmental sample （17/33, 51.52%） （Zz： 13. 165, P〈0.01）. The most common mammography features of triple negative breast cancer were simple mass （25/32, 78.13%） with smooth edges （18/26, 69.23%） （χ^2=26.247,P〈0.01） （χ^2= 33.617, P〈0.01） and the mass diameter more than 5cm （16/26, 61.54%） （χ^2=10.664, P〈0.05）. The most common mammography features of HER-2 overexpression breast cancer was simple calcification （16/29, 55.170%） （χ^2=25.948, P 〈0.01）, and clustered calcification （13/22, 59.09%） （χ^2=12.803, P〈0.01） was found in most common calcification sample. The most common mammography features of Luminal A breast cancer was mass with marginal burr （9/15, 60.00%） （χ^2= 21. 234, P〈0.01）. Conclusion The mammography features has comparative relationship with molecular phenotypes of young breast cancer, which provides reference value for predicting biological characteristics and prognosis for young breast cancer patients.