丁苯酞注射液治疗急性脑梗死的临床疗效及定量脑电图分析

Analysis of Clinical Curative Effect of Dl-3-n-butyphthalide Injection in Treatment of Acute Cerebral Infarction and Quantitative Electroencephalogram

目的观察丁苯酞氯化钠注射液治疗急性期脑梗死患者的临床疗效,以及定量脑电图对急性期脑梗死患者临床疗效的监测意义。方法将80例急性脑梗死患者随机分为治疗组和对照组,治疗组在常规治疗的基础上给予丁苯酞氯化钠注射液治疗。比较两组治疗前后美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分、Barthel指数评分和定量脑电图(quantitative electroencephalogram,QEEG)慢波化比率(Deltaratio,Symmetry theta/alpha+beta rate,DTABR)等数据。结果治疗14 d后,治疗组NIHSS评分[(3.58±2.72)分vs(6.33±2.63)分]、Barthel指数评分[(68.20±26.83)分vs(66.12±24.45)分]、DTABR[(2.83±1.20)分vs(4.10±1.72)分]的变化优于对照组,差异有统计学意义。结论丁苯酞氯化钠注射液治疗急性脑梗死患者临床疗效显著且定量脑电图对急性脑梗死患者临床疗效的监测有价值。

Objective To observe the clinical curative effect of dl-3-n-butyphthalide injection in treatment of patients with acute cerebral infarction and the monitoring significance of quantitative electroencephalogram（EEG）.Methods A total of 80 patients with acute cerebral infarction were randomly divided into treatment group and control group. The treatment group were given dl-3-n-butyphthalide injection on the basis of conventional treatment. The National Institute of Health Stroke Scale（NIHSS） score, Barthel index score and quantitative electroencephalogram（QEEG）, Deltaratio, Symmetry theta/alpha＋beta rate（DTABR） were compared in two groups before and after treatment respectively.Results After 14 days of treatment, the change of the NIHSS score [（3.58±2.72） vs（6.33±2.63）], the Barthel index score [（68.20±26.83） vs（66.12±24.45）], and DTABR [（2.83±1.20） vs（4.10±1.72）] in treatment group were superior to control group, the difference of which had statistical significance.Conclusion The clinical curative effect dl-3-n-butyphthalide injection treatment in patients with acute cerebral infarction is distinct and the monitoring of QEEG in patients with acute cerebral infarction is of great value.