血清CA125、NSE、CYFRA21-1及SCCA联合检测对肺癌的诊断价值研究

Study on diagnostic value of combined detection of serum CA125, NSE, CYFRA21-1 and SCCA in lung cancer

目的探讨血清糖类抗原125(CA125)、神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)及鳞状小细胞癌抗原(SCCA)联合检测对肺癌的诊断价值。方法选取72例肺癌患者作为观察组(小细胞癌20例,鳞癌36例,腺癌16例),另选取72例健康人作为常规组。两组均进行血清CA125、NSE、CYFRA21-1及SCCA检测。观察比较两组的CA125、NSE、CYFRA21-1、SCCA水平及其阳性率。结果观察组小细胞癌、鳞癌、腺癌患者的CA125、NSE、CYFRA21-1、SCCA水平均高于常规组,差异均具有统计学意义(P<0.05)。观察组患者CA125、NSE、CYFRA21-1、SCCA的阳性率分别为58.33%、69.44%、88.89%、83.33%,均高于常规组的0、0、0、0,差异均具有统计学意义(P<0.05)。结论血清CA125、NSE、CYFRA21-1、SCCA联合检测对肺癌诊断价值较高,可以对肺癌进行鉴别诊断、分析癌症类型以及病情严重程度,有助于医师开展针对性治疗,从而改善患者预后。

Objective To discuss the diagnostic value of combined detection of serum carbohydrate antigen 125（CA125）, neuron specific enolase（NSE）, cytokeratin 19 fragment（CYFRA21-1） and squamous cell carcinoma antigen（SCCA） in lung cancer. Methods There were 72 lung cancer patients as observation group（20 cases of small cell carcinoma, 36 cases of squamous cell carcinoma and 16 cases of adenocarcinoma）, and 72 healthy people as routine group. Serum CA125, NSE, CYFRA21-1 and SCCA were detected in all two groups. The levels of CA125, NSE, CYFRA21-1 and SCCA and their positive rates were observed and compared in the two groups. Results The observation group had higher CA125, NSE, CYFRA21-1 and SCCA level in small cell carcinoma, squamous cell carcinoma and adenocarcinoma cases than routine group, and their difference was statistically significant（P〈0.05）. The observation group had positive rate of CA125, NSE, CYFRA21-1 and SCCA respectively as 58.33%, 69.44%, 88.89% and 83.33%, which were all higher than 0, 0, 0 and 0 in the routine group, and their difference was statistically significant（P〈0.05）. Conclusion Combined detection of serum CA125, NSE, CYFRA21-1 and SCCA shows high diagnostic value for lung cancer, and it can identify the lung cancer, analyze the type of cancer and the severity of the disease, which is helpful for doctors to carry out targeted treatment and improve the prognosis of patients.