血必净对创伤性脑损伤后肺损伤炎症因子的影响

Effect of Xuebijing on inflammatory factor of lung injury after traumatic brain injury

目的 探讨血必净治疗创伤性脑损伤后肺损伤的效果.方法 构建创伤性脑损伤后肺损伤的大鼠模型90例,按照随机分组法分为生理盐水组、TBI模型组及血必净干预组三组,每组30例.统计分析三组炎症因子C反应蛋白的情况.结果 治疗24 h时,生理盐水组、TBI模型组及血必净干预组大鼠炎症因子C反应蛋白水平分别为（64.42±13.22）mg/L、（63.85±14.36）mg/L及（63.83±13.51）mg/L,三组比较差异无统计学意义（P〉0.05）;治疗7、14及21 d时,血必净干预组大鼠炎症因子C反应蛋白水平分别为（31.52±10.02）mg/L、（21.35±9.54）mg/L及（13.14±3.06）mg/L,明显优于生理盐水组及TBI模型组,差异有统计学意义（P〈0.05）.结论 运用血必净治疗创伤性脑损伤后肺损伤,可显著改善炎症因子C反应蛋白水平,可进行有效普及推广.

Objective To investigate the application value of Xuebijing in treatment of lung injury after traumatic brain injury. Methods A total of 90 rats with traumatic brain injury models were estab-lished and randomly divided into the physiological saline group,TBI model group and Xuebijing intervention group,with 30 cases in each group. The inflammatory factor C-reactive protein was statistically significantly analyzed. Results After 24 hours of treatment,the inflammatory factor C-reactive protein in the physiologi-cal saline group,TBI model group and Xuebijing intervention group were（64. 42 ± 13. 22）mg/L,（63. 85 ± 14. 36）mg/L and（63. 83 ± 13. 51） mg/L,and there was no statistically significant difference between the three groups（ P 〉0. 05 ） . The inflammatory factor C-reactive protein in the Xuebijing intervention group were（31.52 ±10.02）mg/L at Day 7,（21.35 ±9.54）mg/L at Day 14 and（13.14 ±3.06）mg/L at Day 21,which were significantly better than those in the physiological saline group and TBI model group（ P〈0. 05）. Conclusion Xuebijing in treatment of lung injury after trauma brain injury can significantly im-prove the level of inflammatory factor C-reactive protein,which is worth to be clinical promoted.