长期服用非甾体抗炎药患者感染幽门螺杆菌的相关因素研究

Related factors of helicobacter pylori infection in patients with long-term administration of non-steroidal anti-inflammatory drugs

目的分析长期服用非甾体抗炎药患者感染幽门螺杆菌的相关因素。方法选择120例长期服用非甾体抗炎药患者,均给予13C呼吸试验,统计幽门螺杆菌(Hp)阳性例数,记录患者年龄、性别、饮食习惯、吸烟史、饮酒史、文化程度、心理状况,胃炎或胃溃疡家族史,应用Logistics回归分析获得Hp感染的相关因素。结果长期服用非甾体抗炎药120例患者中,Hp阳性69例(57.50%),Hp阴性51例(42.50%)。高龄、有吸烟及饮酒史、有胃炎或胃溃疡家族史、焦虑或抑郁的长期服用非甾体抗炎药者Hp阳性检出比例较高(P<0.05)。Logistics多因素回归提示,高龄、有吸烟饮酒史、有胃炎或胃溃疡家族史、饮食不规律、有焦虑或抑郁等因素是Hp感染的独立相关因素。结论长期服用非甾体抗炎药患者易感染幽门螺杆菌,两者可协同作用损伤胃黏膜,Hp感染与患者年龄、饮食习惯、吸烟饮酒、家族史等因素密切相关。

Objective To investigate the related factors of helicobacter pylori infection in pa- tients with long-term administration of non-steroidal anti-inflammatory drugs （NSAIDs）. Methods A to- tal of 120 patients with long-term use of NSAIDs were selected and treated by 13C breath test, and the number of positive cases of helicobacter pylori （Hp） was counted. The age, sex, eating habits, smoking history, drinking history, education level, psychological status, family history of gastritis or gastric ulcer of the patients were recorded, and the related factors of Hp infection were obtained by logistics regression analysis. Results Among the 120 patients with long-term use of NSAIDs, there were 69 cases （57.50%） of positive Hp and 51 cases （42. 50% ） of negative Hp. The detection rate of positive Hp was higher in patients of elderly, or with smoking and drinking history, family history of gastritis or gas- tric ulcer, anxiety or depression （P 〈 0. 05 ）. It was found by logistic regression analysis that elderly, smoking and drinking history, family gastritis/gastric ulcer history, irregular diet, anxiety or depression are independent factors related to Hp infection. Conclusions Long-term administration of NSAIDs is easy to infect helicobacter pylori, which can synergistically affect gastric mucosa. Hp infection is closely related to patients＇ age, eating habits, smoking and drinking, family history and other factors.