奥硝唑不同用药方案治疗慢性盆腔炎的临床效果与安全性

Effects of different medication plans of ornidazole on chronic pelvic inflammation

目的评价奥硝唑＋头孢地尼、奥硝唑＋左氧氟沙星、奥硝唑单独用药对慢性盆腔炎的疗效与安全性。方法选取231例慢性盆腔炎患者，根据随机数字表法，分为A、B、c三组，每组77例。A、B、C三组患者分别接受奥硝唑单独用药、奥硝唑＋左氧氟沙星、奥硝唑＋头孢地尼治疗。治疗前后，比较各组患者的红细胞压积、白细胞介素-1（IL-1）、淋巴细胞计数、血浆黏度、C-反应蛋白（CRP）、白细胞计数、不良反应发生情况与淋巴细胞百分比等指标及总有效率。结果治疗后，C组患者总有效率显著高于A组（94．8％比62．3％，χ^2=24．105，P〈0．01）与B组（94．8％比83．2％，χ^2=8．381，P=0．004）。治疗后各组患者红细胞压积、IL-1、淋巴细胞计数、血浆黏度、CRP、淋巴细胞百分比、白细胞计数指标均较治疗前显著改善，差异有统计学意义（P〈0．05）。B组患者以上指标治疗后均显著低于A组，C组患者以上指标治疗后均显著低于A组与B组，差异有统计学意义（P〈0．05）。结论在进行常规治疗的同时，头孢地尼联合奥硝唑治疗慢性盆腔炎具有良好的疗效，疗效优于奥硝唑单药治疗或左氧氟沙星联合奥硝唑治疗，且安全性好，值得临床推广应用。

Objective To evaluate the efficacy and safety of ornidazole alone, ornidazole ＋ levo- f/oxacin, ornidazole ＋ cefdinir on chronic pelvic inflammatory disease. Methods A total of 231 patients with chronic pelvic inflammatory disease were selected. According to the random number table method, the patients were divided into three groups, with 77 patients in each group. The patients in group A were treated with oruidazole alone, and the patients in group B were treated with ornidazole ＋ levofloxacin, and the patients in group C were treated with Ornidazole ＋ cefdinir treatment. The hematocrit, interleukin-1 （IL-1）, lymphocyte count, plasma viscosity, C-reactive protein （CRP）, white blood cell count, inci- dence of adverse reactions and lymphocyte percentage were compared before and after treatment. The to- tal efficiency of the three groups was compared. Results After treatment, the total effective rate of group C was significantly higher than that of group A （94. 8% vs. 62. 3% , χ^2=24. 105, P 〈0. 001 ） and B group （94. 8% vs. 83.2%, χ^2 =8. 381, P =0. 004）. After treatment, the hematocrit, IL-1, lymphocyte count, plasma viscosity, CRP, lymphocyte percentage and white blood cell count in the three groups were significantly improved compared with those before treatment （ P 〈 0. 05 ）. The above indicators in group B were significantly lower than those in group A after treatment, and those in group C were significantly lower than those in group A and group B after treatment, the differences were significant （ P 〈 0. 05）. Conclusions In the conventional treatment, at the same time, cefdinir combined with Ornidazole treatment has good therapeutic effect on chronic pelvic inflammation. The curative effect is su- perior to ornidazole single drug therapy or levofloxacin combined with Ornidazole. And the safety is good, it is worthy of clinical application.