毛萼清风藤中一个新的氧化阿朴菲碱类化合物

A new oxoaporphine from Sabia limoniacea var. ardisioides

采用硅胶柱色谱、Sephadex LH-20、制备液相等多种色谱技术,对毛萼清风藤的95%乙醇提取物进行分离纯化。从中分离得到了8个化合物,根据化合物的光谱数据和理化性质鉴定为5-甲氧基-1,2-亚甲二氧基氧化阿朴菲碱(1)、5-氧阿朴菲碱(2)、N-p-阿魏酰酪胺(3)、N-反式香豆酰酪胺(4)、槲皮素(5)、芦丁(6)、mutabiloside(7)和原儿茶酸(8)。其中,化合物1为新化合物,化合物2~8均为首次从毛萼清风藤中分离得到。

The chemical constituents of Sabia limoniacea var. ardisioides were investigated using chromatographic methods, such as silica gel, Sephadex LH-20 and preparative HPLC. Eight compounds were isolated and their structures were elucidated by spectral data and physicochemical properties, which were identified as 5-methoxy-1,2-methylenedioxyl oxoaporphine（1）, fuseine（2）, N-p-feruloyltyramine（3）, N-trans-coumaroyl tyramin（4）, quercetin（5）, rutin（6）, mutabiloside（7）, and protocatechuic acid（8）. Among those, compound 1 is a new compound, compounds 2-8 were isolated from this plant for the first time.