银屑病与PD-1相关性研究进展

Progress on Correlation Studies of Psoriasis and PD-1

银屑病(psoriasis)是一种常见免疫介导的,与遗传、代谢等多种因素相关的疾病,目前病因不明。近来越来越多的研究证明了PD-1(Programmed cell death 1)作为表达于效应T细胞表面的免疫受体,在银屑病炎症反应中发挥着重要作用。而其配体PD-L1在银屑病表皮中表达,也与疾病发病息息相关。本文主要从PD-1信号通路,就银屑病发病机制及其对应的治疗进展作一综述。

Psoriasis is a common immune-mediated disease, such as heredity and metabolism, its pathogenesis days, accumulating studies has proved that PD-1 serves as immune receptor working on the surface which relates to multiple factors is still unknown at present. Nowa- （Programmed cell death 1 ） which of T ceils, plays an important role in psoriasis inflammation. Its ligand PD-L1, also expressed in psoriatic epidermis, is closely related to the disease. This review mainly summarizes the pathogenesis of pso- riasis and the progress of its corresponding treatment via PD-1 signaling pathways.