药物性牙龈增生发病机制的研究进展

Research Progress on Mechanisms of Drug-induced Gingival Overgrowth

药物性牙龈增生是指服用药物引起的牙龈增生和体积增大,具有共同的病理组织学特点,而其发病机制目前仍无定论。本综述主要从胶原合成降解、炎症和基因三方面对药物性牙龈增生的发病机制做一综述,对指导医疗专业人员有效防治药物性牙龈增生具有一定参考价值。

Drug-induced gingival overgrowth（DGO）is the gingival hyperplasia and volume enlargement,which is a side effect associated with 3 types of drugs：anticonvulsants,calcium channel blockers,and immunosuppressive agents.It is characterized by some common pathological features.However,the mechanisms and clinical treatment of these disorders have not been elucidated.This review provides an overview of the pathogenesis of drug-induced gingival hyperplasia from three aspects,i.e.collagen synthesis and degradation,inflammation,and genetics,with of great importance in guiding the medical professionals to effectively prevent drug-induced gingival hyperplasia.