慢性酒依赖患者血尿酸水平与踝臂指数的相关性分析

Analysis of correlation between serum uric acid level and ankle brachial index in chronic alcohol-dependent patients

目的:探讨慢性酒依赖患者血尿酸水平(Serum Uric Acid,SUA)与踝臂指数(Ankle Brachial Index,ABI)水平的相关性。方法:选取2016年1月至2017年1月在乌鲁木齐市第四人民医院住院的慢性酒依赖患者209例,按WHO饮酒分类标准以危险饮酒年限大于10年的患者为长期饮酒组(102例),危险饮酒年限小于10年的患者为非长期饮酒组(107例);并纳入无习惯性饮酒嗜好的健康体检者95例为对照组。收集一般临床资料,测定SUA及ABI。同时根据ABI值分为ABI正常组和ABI异常组,分别进行组间比较。结果:ABI异常组的甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、载脂蛋白B、SUA水平均高于ABI正常组,该差异有统计学意义(P<0.05)。长期饮酒组、非长期饮酒组、对照组的TG、TC、LDL-C、SUA、ABI比较存在差异,差异有统计学意义(P<0.05)。长期饮酒组、非长期饮酒组的ABI均低于对照组,长期饮酒组TG、SUA均高于非长期饮酒组及对照组,非长期饮酒组年龄高于对照组,长期饮酒组TC、LDL水平均高于对照组,以上差异有统计学意义(P<0.05)。结论:本研究中慢性酒依赖患者SUA水平与ABI成负相关。

Objective： To investigate the relationship between serum uric acid level and ankle brachial index in patients with chronic alcohol dependence.Methods： From January 2016 to January 2017,209 patients who have chronic drinking dependence in Fourth People ＇s Hospital of Urumqi City were selected,according to the WHO classification standards of chronic alcohol drinking,patients who have drunk more than 10 years were divided into long-term drinking group（ 102 cases）,the patients who have dangerous drinking less than 10 years were divided into non drinking group（ 107 cases）; 95 healthy cases who don＇t have habitual alcohol addition were chosen as control group. Clinical data were collected and SUA and ABI were measured. At the same time,according to the ABI value,it was divided into ABI normal group and ABI abnormal group.Results： The levels of triglyceride（ TG）,total cholesterol（ TC）, low density lipoprotein（ LDL-C）,apolipoprotein B and SUA in the abnormal ABI group were higher than those in the ABI group,the difference was statistically significant（ P〈0. 05）. There were significant differences in TG,TC,LDL-C,SUA and ABI between the long-term drinking group,the non long term drinking group and the control group（ P〈0. 05）. Long term drinking group,non long term drinking group ABI were lower than the control group,the long-term drinking group TG and SUA was higher than that of non long term drinking group and control group,non long term drinking group was higher than the control group,LDL group,TC level of long-term alcohol consumption were higher than the control group,there were significant differences over them（ P〈0. 05）.Conclusion： In this study,the level of SUA in patients with chronic alcohol dependence was negatively correlated with ABI.