4-羟基香豆素衍生物的微波合成、表征及抗凝血研究

Microwave synthesis,characterization and anticoagulant study of novel 4-hydroxy coumarin derivatives

目的:采用微波合成法合成12种新型香豆素衍生物。方法:本文以天然产物4-羟基香豆素为原料,采用微波合成法合成了系列新型香豆素衍生物,所有产物进行了IR,MS,~1HNMR结构表征。结果:其中部分产物为首次合成,对新合成的一种化合物进行抗凝血研究。结论:实验结果表明该化合物具有显著的抗凝血作用,为此类抗凝血药物的研究提供了重要的理论基础。

Objective：To synthesize twelve new coumarin derivatives by microwave synthesis.Methods：A series of new coumarin derivatives were synthesized from 4-hydroxycoumarin by microwave synthesis method.All the products were characterized by IR,MS and ～1HNMR.Results：Some of the compounds were synthesized for the first time,for one of which the anticoagulant effect was studied.Conclusion：The experimental results showed that the compound has significant anticoagulant effect,which provide an important theoretical basis for the study of anticoagulant drugs.