翼状胬肉切除术联合自体角膜缘干细胞移植术治疗翼状胬肉的疗效观察

Pterygium excision combined with autologous corneal limbal stem cell transplantation for patients with peterygium

目的 比较单纯翼状胬肉切除术与联合自体角膜缘干细胞移植术治疗翼状胬肉的临床疗效.方法 选择2015年3月至2016年5月本院收治的42例（66眼）翼状胬肉患者,随机分为观察组和对照组,各33眼.术后随访6个月.结果 术后观察组裸眼视力高于对照组[（0.83±0.15）比（0.73±0.15）],差异有统计学意义（P＜0.01）;观察组患者的角膜上皮修复时间以及拆线时间均短于对照组[（2.12±0.68）d比（2.67±0.96）d,（4.97±0.81）d比（5.70±0.92）d],差异均有统计学意义（均P＜0.05）.治疗后,观察组患者的治愈率高于对照组（93.94％比75.76％）,差异有统计学意义[P＜0.01）.结论 自体角膜缘干细胞移植术治疗翼状胬肉是可行的,能有效提高患者的生活质量,防止翼状胬肉的复发.

Objective To analyze the effect of pterygium excision combined with autologous limbal stem cell transplantation for patients with pterygium. Methods 42 pterygium patients （66 eyes） treated at our hospital from March, 2015 to May, 2016 were included into the study; Using random number table method, they were divided into a control group and an observation group, 33 eyes for each group. The control group were treated with pterygium excision and the observation group with pterygium excision and autolgous corneal limbal stem cell transplantation. Both groups were followed by 6 months. Results After the surgery, the uncorrected visual acuity was higher in the observation group than in the control group [（0.83±0.15） vs. （0.73±0.15）]. The corneal epithelial repair time and stitches-off time were shorter in the observation group than in the control group [（2.12±0.68） d vs. （2.67±0.96） d and （4.97±0.81） d vs. （5.70±0.92） d], with statistical differences （both P〈0.05）. After the treatment, the cured rate was higher in the observation group than in the control group （93.94% vs. 75.76%）, with a statistical differences （P〈0.01）. Conclusion Pterygium excision combined with limbal stem cell translations has good overall effect and can improve the pterygium corneal astigmatism and vision.