柯萨奇病毒A组10型研究进展

Progress in coxsackievirus A10

自2008年以来,由多种肠道病毒引起的手足口病已成为严重威胁中国婴幼儿健康的重大公共卫生问题之一。其中,肠道病毒71型(enterovirus 71,EV71)和柯萨奇病毒A组16型(coxsackievirus A16,CVA16)是引起手足口病的主要病原体。但2011年以后,中国手足口病的流行趋势发生了变化,柯萨奇病毒A组10型(coxsackievirus A10,CVA10)和柯萨奇病毒A组6型(coxsackievirus A6,CVA6)引起的手足口病呈增多趋势,在部分地区已替代EV71和CVA16成为引起手足口病的主要病原体,已引起越来越多的关注。现就CVA10的病原学、流行病学、实验室诊断、动物模型及疫苗相关研究作一综述。

Human hand, foot, and mouth diseases （HFMD） have become one of major public health problems, in which were involved various enterovirus and severely threaten infant and child health in China since 2008, and enterovirus 71 （EV71） and coxsackievirus A16（CVA16） are the major pathogens of HFMD. However, the prevalence of HFMD changed after 2011 in China, and the epidemic of CVA10 and coxsackievirus A6（CVA6） has increased. These two pathogens have replaced EV71 and CVA16, and have become major pathogens causing HFMD in some areas, which is a growing concern. The paper reviews on CVAIO related pathogenicity, epidemiology, laboratory diagnosis, development of vaccine and set up animal models.