健康相关生命质量评价在自身免疫性肝炎诊治中的应用价值

The application value of health related quality of life in autoimmune hepatitis

自身免疫性肝炎是一种由自身免疫反应介导的肝实质炎症。本病呈全球性分布，女性易患。临床表现多样，一般呈慢性隐匿起病，也可表现为急性发作，甚至肝功能衰竭。病程长、治愈率低、治疗费用高等因素易导致患者产生心理、社会、情感障碍，进而影响患者生活质量和治疗依从性。健康相关生命质量目前被广泛用于评估个体健康状态。本文主要综述健康相关生命质量在自身免疫性肝炎领域中的应用价值，以提高医护关注患者情感心理健康状况，正确评估，早期干预，改善患者健康相关生命质量，提升本病疗效。

Autoimmune Hepatitis （AIH） is an autoimmunity mediated inflammatory liver disease characterized by high levels of auto-antibodies, hypergamma globulinemia, and interface hepatitis. AIH is a global distribution disease and primarily affects women. AIH has diverse clinical manifestations such as asymptom acute hepatitis and liver failure. The management presents a long course of drug treatment, dismal prognosis and high medical costs, which could lead to psychological disorder and adverse effect on the compliance and Health Related Quality of Life （HRQOL）. Here, we review the application value of HRQOL in AIH.