泮托拉唑与奥美拉唑治疗消化道溃疡合并出血的临床效果

Clinical Effect of Pantoprazole and Omeprazole in Treatment of Peptic Ulcer Complicated with Bleeding

目的本文就泮托拉唑与奥美拉唑治疗消化道溃疡合并出血的临床效果进行对比。方法选取我科收治的94例消化道溃疡合并出血患者,依据入院顺序单双号进行分组,47例单号者设为实验组,采用半托拉唑治疗;47例双号者设为参照组,采用奥美拉唑治疗;比较二组的疗效。结果实验组患者的治疗总有效率为97.87%,稍高于参照组的93.62%,但组间比较无统计学意义(P>0.05);两组不良反应发生率比较也无差异(P>0.05);实验组患者的出血量少于参照组,止血时间对比参照组更快,实验组治疗后的PH值也高于参照组,组间比较有显著差异(P<0.05)。结论应用泮托拉唑与奥美拉唑治疗消化道溃疡合并出血均有显著效果,且药物安全性高,但泮托拉唑的抑酸、止血效果更好,更具临床应用及推广价值。

Objective To compare clinical effect of pantoprazole and omeprazole in treatment of peptic ulcers with bleeding. Methods Choose 94 cases peptic ulcer hemorrhage patients in our department, according to admission sequence, 47 cases odd numbers were included in experimental group, treated with pantoprazole; 47 cases even numbers were included in control group, with omeprazole. Compare curative effect of two groups. Results Total effective rate of experimental group was 97.87%, slightly higher than 93.62% of control group, with no significant differences between two groups（P〈0.05）; adverse reactions incidence also showed no difference（P〉0.05）; bleeding amount of experimental group was less than control group, hemostasis time was less. After treatment, p H value of experiment group was higher than control group, difference was significant between groups（P〈0.05）. Conclusion Both pantoprazole and omeprazole are effective in treatment of peptic ulcer bleeding, with high safety. And pantoprazole has better effect on inhibiting acid and hemostasis, which has more clinical application and promotion value.