阿托伐他汀联合缬沙坦治疗慢性肾炎的疗效及对C反应蛋白的影响

Effect of Atorvastatin Combined with Valsartan in Treatment of Chronic Nephritis and its Effect on C Reactive Protein

目的探究阿托伐他汀联合缬沙坦治疗慢性肾炎的疗效及对C反应蛋白的影响。方法选择2016年2月至2017年2月于我院就诊的慢性肾炎患者,共70例,按进入院编号随机分为两组,每组35例。对照组采用阿托伐他汀治疗,观察组给予阿托伐他汀联合缬沙坦治疗,比较两组患者的治疗效果。结果观察组治疗24 h尿蛋白定量、C反应蛋白和血压的改善情况明显优于对照组,具有统计学意义(P<0.05);但两组患者在不良反应方面的比较,无统计学意义(P>0.05)。结论在治疗慢性肾炎时,联合应用阿托伐他汀与缬沙坦治疗,有助于治疗效果显著增强,促进C反应蛋白的改善,值得临床应用。

Objective To explore effect of atorvastatin combined with valsartan in treatment of chronic nephritis and its effect on C reactive protein. Methods Choose 70 cases chronic nephritis patients in our hospital from February 2016 to February 2017, divide them into two groups randomly according to admission number, 35 cases in each. Control group was treated with atorvastatin, and observation group with atorvastatin combined with valsartan. Compare treatment effect of two groups. Results 24 h after treatment, improvement of urinary protein, C reactive protein and blood pressure of observation group was significantly better than control group, with statistical significance（P〈0.05）, adverse reactions difference showed no statistical significance between two groups（P〉0.05）. Conclusion Atorvastatin combined with valsartan can improve curative effect significantly, promote improvement of C reactive protein in treatment of chronic glomerulonephritis, which is worthy of clinical application and promotion.