特发性肺间质纤维化合并肺气肿与未合并肺气肿患者的临床对比研究

Clinical Comparative Study on Patients with Idiopathic Pulmonary Fibrosis Combined with Emphysema and No Emphysema

目的研究对比特发性肺间质纤维化合并肺气肿与未合并肺气肿患者的临床特征。方法选取30例我院收治的特发性肺间质纤维化合并肺气肿患者,和30例单纯特发性肺间质纤维化患者,对两组患者的临床资料做回顾性分析。结果观察组患者的VC、TLC、FEV1/FVC与对照组相比,P<0.05。观察组患者的DLCO与对照组相比,P>0.05。观察组胞总数、NE、AM、LY与对照组差异不明显,同时满足P>0.05,无统计学意义。经过治疗后进行随访,观察组患者生存时间与和死亡与对照组无差异,且P>0.05,无统计学意义。结论是否合并肺气肿对患者的治疗和预后无明显影响,吸烟是特发性肺间质纤维化的危险因素。

Objective To study and compare clinical features of patients with pulmonary interstitial fibrosis combined with emphysema and no emphysema. Methods Choose 30 cases idiopathic pulmonary fibrosis and emphysema patients in our hospital and 30 cases only idiopathic pulmonary fibrosis patients, review and analyze their clinical data. Results VC, TLC and FEV1/FVC of observation group showed P〉0.05 compared with control group. DLCO of observation group showed P〈0.05 compared with control group. Total cell numbers, NE, AM, LY of of observation group showed no significant difference from control group, P〉0.05, with no statistical significance. After treatment and followup, survival time and death of observation group showed no difference from control group, P〉0.05, with no statistical significance. Conclusion Combination with emphysema has no significant effect on treatment and prognosis of patients, and smoking is a risk factor of idiopathic pulmonary fibrosis.