冠状动脉慢血流患者的随访性研究

A Follow-up Study on the Patients with Slow Coronary Flow

目的:探讨冠状动脉慢血流患者(CSFP)的临床结局。方法:收集我院2010年9月至2015年9月因疑似冠心病行冠状动脉造影检查且证实为CSFP的患者553例作为实验组及冠状动脉血流正常者333例作为对照组。比较两组患者的病史资料、实验室检查及随访信息,分析冠状动脉慢血流现象的临床结局。结果:CSFP组男性、吸烟、高运动量、高血压、服药患者比例、脑血管病发生率、心脏事件死亡率、冠状动脉狭窄率均显著高于对照组(P<0.05)。与对照组比较,CSFP组脑血管疾病发生率显著高于对照组(P=0.0037)。慢血流组发生脑血管事件者生存率低于对照组。Logistic多元回归分析结果显示:慢血流(HR=5.85,95%可信区间2.00-17.15,P<0.01)和年龄(HR=1.07,95%可信区,1.03-1.11,P<0.01)为发生脑血管病的独立危险因素。结论:慢血流组患者发生脑血管疾病、冠状动脉狭窄及因心脏事件死亡者显著升高,冠状动脉慢血流及年龄为发生脑血管病的独立危险因素。

Objective： To study the clinical outcomes of patients with coronary slow flow （CSFP）. Methods： From September 2010 to September 2015, 553 cases of patients with angiographically proven CSFP were selected and compared with 333 cases of patients with normal coronary flow in this study. The clinical data, laboratory examination and follow-up information of two groups of patients were compared. The clinical outcomes of coronary slow flow phenomenon was analyzed. Results： The proportion of male, smoker, high exercise capacity, hypertension, patients taking medicine, stroke, cardiac death and coronary stenosis in CSFP group were all significantly higher than those in the normal group. Compared with the control group, the incidence of stroke was signifcantly higher in the CSFP group（P=0.0037）. The stroke survival rate in CSFP group was lower than that of the control group. Logistic multivariate regression analysis revealed CSF（HR=5.85, 95% CI 2.00-17.15, P〈0.01） and age （HR=1.07, 95% CI 1.03-1.11, P〈0.01） as the independent predictors of stroke. Conclusion： CSFP patients had high risk of stroke, cardiac death and coronary stenosis. CSF and age were independent predictors of stroke.