丁苯酚联合尼莫地平对急性脑出血患者神经功能及血清MMP-9、NF-κB水平的影响

Effect of Dl-3-butylphthalide Combined with Nimodipine on the Serum of MMP-9, NF-κB Levels and Neurological Function of Patients with Acute Cerebral Hemorrhage

目的:探讨丁苯酚联合尼莫地平对急性脑出血患者及神经功能及血清基质金属蛋白酶9(MMP-9)和核转录因子kappa B(NF-κB)水平的影响。方法:选择90例急性脑出血患者作为研究对象并将其随机分为两组,每组各45例。两组患者均给予口服尼莫地平片治疗,观察组在对照组基础上加以口服丁苯酚软胶囊,疗程均为30天。比较两组患者的临床疗效以及治疗前后血清MMP-9、NF-κB水平和神经功能的变化。结果:观察组患者的临床总有效率显著高于对照组[42(93.99%)vs 37(82.22%)](P<0.05)。治疗后,观察组的血清MMP-9、NF-κB水平均明显低于对照组[121.51±14.76 vs 137.09±14.71;0.14±0.04vs0.24±0.05](P<0.05),日常生活质量评分(ADL)明显高于对照组[37.09±5.91 vs 33.54±6.74](P<0.05),神经功能缺损评分(NIHSS)明显低于对照组[15.31±7.61 vs18.54±5.21](P<0.05),认知功能评分(MMSE)明显高于对照组[27.54±4.21vs23.72±5.75](P<0.05)。结论:丁苯酚联合尼莫地平治疗急性脑出血患者的临床疗效优于口服尼莫地平片单药治疗,可有效改善患者的神经和认知功能,可能与其显著降低血清MMP-9、NF-κB水平有关。

Objective： To investigate the effect of D1-3-butylphthalide combined with nimodipine on the Serum ofMMP-9, NF-κB levels and Neurological function of Patients with Acute Cerebral Hemorrhage. Methods： 90 cases of patients with acute cerebral hemorrhage were selected as the research object and randomly divided into two groups, 45 cases in each group. Both groups of patients were given oral nimodipine treatment, the observation group was given butyl phenol on the basis of control group, 30 days was considered as a treatment cycle. The clinical efficacy, changes of serum levels of MMP-9, NF-kappa B and neurological function before and after treatment were compared between two groups. Results： The total effective rate of observation group was significantly higher than that of the control group （93.99% vs 37 82.22%）]（P〈0.05）. After treatment, the serum levels ofMMP-9, NF-kappa B of observation group were significantly lower than those of the control group （121.51± 14.76 vs. 137.09± 14.71; 0.14± 0.04 vs. 0.24± 0.05）（P〈0.05）, the quality of life scale （ADL） was significantly higher than that of the control group （37.09± 5.91 vs. 33.54± 6.74] （P〈0.05）, and the neurological function defect score （NIHSS） scores was significantly lower than the control group （15.31±7.61 vs18.54± 5.21）（P〈0.05）, the cognitive function score （MMSE） was significantly higher than that of the control group （27.54 ± 4.21 vs 23.72 ± 5.75] （P〈0.05）. Conclusion： DI-3-butylphthalide combined with nimodipine was more effective than nimodipine alone in the treatment of acute cerebral hemorrhage patients, it could effectively improve the neurological and cognitive function, which might be related to the reduction of serum levels of MMP-9, NF-kappa B.