细菌纤维素复合抗菌敷料的研究进展

Advances in the research of antibacterial composite dressings based on bacterial cellulose

细菌纤维素是一种由微生物产生的细胞外多糖，是由β-D-葡萄糖通过β-1，4-糖苷键结合成的直链分子。与植物纤维素相比，其没有木质素和半纤维素等伴生产物，具有高合成率、广泛的合成原料来源、良好的机械性能、高密度和结晶度、高可塑形性、大比表面积、高透气性、高持水性、纳米级精细三维网络结构、良好的生物可降解性和生物相容性等特性。因此细菌纤维素在组织工程支架、人工血管、人工皮肤等方面具有广泛应用前景，是目前国际生物医用材料研究的热点。本文主要综述细菌纤维素复合抗菌敷料的研究进展。

Bacterial cellulose （BC） is a promising material for wound dressing due to its predominant water binding capacity, mechanical property, biodegradability, and histocompatibility. Whereas BC itself exhibits no antimicrobial activity. To gain antimicrobial activity, several kinds of antibacterial agents have been introduced into BC. However, all of the antibacterial composite dressings are still in the stage of experimental research. In this paper, the types, antibacterial mechanism, and shortcomings of antibacterial composite dressings based on BC are summarized, in order to make prospects of the research trends of antibacterial composite dressings based on BC in future.