Nanog、Snail在宫颈上皮内瘤变及宫颈癌中的表达及临床意义

Expression and clinical significance of Nanog and Snail in cervical carcinoma and cervical intraepithelial neoplasia

目的探讨宫颈癌中Nanog和Snail的表达及临床意义。方法应用免疫组织化学SP法检测60例宫颈癌、20例宫颈上皮内瘤变和20例正常宫颈上皮组织中Nanog和Snail的表达情况。结果Nanog和Snail在宫颈上皮内瘤变和宫颈癌组织中的阳性表达增强,其中Nanog和Snail在宫颈癌中的表达显著增强。Nanog和Snail的表达呈正相关(r=0.457;P<0.01)。患者年龄、组织学分型、分化程度对Nanog和Snail阳性表达率无影响,但Nanog和Snail的表达与临床分期有关(P<0.05)。结论Nanog和Snail在宫颈癌组织中高表达,Nanog和Snail有可能成为宫颈癌的生物学标志。

Objective To explore the expression and clinical significance of Nanog and Snail in cervical cancer. Methods Immunohistochemical SP method was used to test the expression of Nanog and Snail in 60 cases of cervical carcinoma, 10 cases of cervical intraepithelial neoplasm （CIN） and 10 cases of normal cervical tissues. Results The positive expression of Nanog and Snail in cervical intraepithelial neoplasia and cervical cancer was enhanced and their expression in cervical cancer was significantly enhanced. The expression of Nanog and Snail were positively correlated （r=0.457; P〈0. 01）. The age, histological type and differentiation degree had no effect on the positive expression of Nanog and Snail, but the positive expression was related to the clinical stage （P=0.020）. Conclusion Nanog and Snail are highly expressed in cervical cancer tissues. Nanog and Snail may become biological markers of cervical cancer.