加巴喷丁在神经根型颈椎病治疗中的应用观察

Application of Gabapentin in the Treatment of Cervical Spondylopathy

目的分析加巴喷丁治疗神经根型颈椎病的疗效。方法将70例神经根型颈椎病患者,按照硬币法将其分为研究组和对照组,每组35例。对照组患者采用常规药物治疗,研究组在对照组的基础上加用加巴喷丁治疗,对两组患者的治疗效果、不良反应发生率、免疫学指标、疼痛程度进行比较,运用SPSS19.0软件,所获数据采用t检验和2检验。结果两组患者治疗效果比较,P<0.05。两组患者治疗前的疼痛评分比较,P>0.05;两组治疗后疼痛评分比较,P<0.05。同组治疗前后疼痛评分比较,P>0.05。两组患者治疗前,白细胞总数、淋巴细胞绝对值、中性粒细胞绝对值、单核细胞绝对值、C3、C4、Ig A、Ig G、Ig M比较,P>0.05;两组患者治疗后白细胞总数、淋巴细胞绝对值、中性粒细胞绝对值、单核细胞绝对值、C3、C4、Ig A、Ig G、Ig M比较,P<0.05。同组治疗前后,白细胞总数、淋巴细胞绝对值、中性粒细胞绝对值、单核细胞绝对值、C3、C4、Ig A、Ig G、Ig M比较,P<0.05。两组患者不良反应发生率比较,P>0.05。结论采取加巴喷丁对神经根型颈椎病患者进行治疗可获得较好的疗效,且不良反应少,安全性高。

Objective To analyze the efficacy of gabapentin in the treatment of cervical spondylotic myelopathy. Methods Seventy patients with cervical spondylotic myelopathy admitted to our hospital were included in this experiment. All cases were selected from January 2016 to June 2017. They were divided into study group （35 cases） and control group according to the coin method. The group （35 cases） and control group were treated with conventional drugs. The study group was treated with gabapentin on the basis of the control group. The treatment effect, incidence of adverse reactions, immunological parameters, and pain were compared between the two groups of patients. SPSS 19.0 software performs statistical analysis of the data. Results The treatment effects of the two groups were compared, P〈0.05. The pain scores before treatment in the two groups were compared, P〉0.05; pain scores after treatment in both groups were compared, P〈0.05. The pain scores before and after treatment in the same group were compared, P〉0.05. Before treatment, the total leukocyte count, absolute lymphocyte count, neutrophil absolute value, absolute monocyte count, C3, C4, IgA, IgG, and IgM were compared before treatment. P〉0.05; total leukocyte counts after treatment in both groups. Absolute lymphocyte count, neutrophil absolute value, absolute mononuclear cell count, C3, C4, IgA, IgG, IgM, P〈0.05. Before and after treatment in the same group, the total number of white blood cells, absolute lymphocytes, absolute neutrophil, absolute mononuclear cells, C3, C4, IgA, IgG, IgM were compared, P〈0.05. The incidence of adverse reactions in the two groups was compared, P〉0.05. Conclusion Gabapentin has good curative effect on the treatment of patients with cervical spondylotic nerve root disease, with fewer adverse reactions and high safety.