辅助生殖技术治疗多囊卵巢综合征不孕患者的临床疗效研究

Clinical Effect Study of Assisted Reproductive Technology in Treatment Infertile Patients with Polycystic Ovary Syndrome

目的研究辅助生殖技术在多囊卵巢综合征(PCOS)不孕患者中的临床疗效。方法选取2013年1月至2016年1月在我院产科分娩的多囊卵巢综合征不孕患者351例为研究对象,分为辅助生殖技术助孕妊娠组及自然妊娠组,比较两组患者的并发症、分娩方式及新生儿一般情况。结果辅助生殖技术组双胎率为22.8%,高于自然妊娠组的2.2%(P<0.05);辅助生殖技术组的双胎PCOS孕妇的胎儿生长受限以及早产发生率较自然妊娠组高(P<0.05);两组的主要分娩方式均为剖宫产,辅助生殖技术组剖宫产率为75.3%,高于自然妊娠组的55.1%(P<0.05);两组出生的低出生体重儿比例、新生儿男女比例及新生儿结局比较差异无统计学意义(P>0.05)。结论多囊卵巢综合征不孕患者经辅助生殖技术助孕妊娠的双胎率及早产率升高,对新生儿结局的影响还有待明确。

Objective To study clinical effect of assisted reproductive technology for polycystic ovary syndrome（PCOS） infertile patients. Methods Choose 351 cases infertility PCOS patients in obstetrics department of our hospital from January 2013 to January 2016 obstetric delivery of polycystic ovary as research objects, divide them into assisted reproductive technology pregnancy group and spontaneous pregnancy group, compare complications, delivery mode and neonatal situation of two groups. Results Twin pregnancy rate of assisted reproductive technology group was 22.8%, higher than natural pregnancy group, 2.2%（P〈0.05）; fetal growth restriction, incidence of premature delivery of twin PCOS pregnant women in assisted reproductive technology group was higher than natural pregnancy group,（P〈0.05）; main delivery mode of two groups was cesarean section, cesarean section rate of assisted reproduction technology group was 75.3%, higher than 55.1% of natural pregnancy group（P〈0.05）; difference of low birth weight ratio, newborn sex ratio and neonatal outcome of two groups showed no statistical significance,（P〈0.05）. Conclusion Assisted reproductive technology can increase twin pregnancy rate and premature delivery rate of polycystic ovary syndrome patients, but effect on newborn＇s outcome need to be clarified.