妊娠合并甲状腺功能异常:子痫前期风险与防范

Thyroid dysfunction in pregnancy:risk of preeclampsia and prevention

妊娠期甲状腺功能异常性疾病通常表现为妊娠期甲状腺功能亢进(甲亢)或妊娠期甲状腺功能减退症(甲减),未经治疗的妊娠期甲状腺功能异常可导致多种母儿并发症并引起不良妊娠结局,无论是甲亢还是甲减均可增加子痫前期的发病风险,且子痫前期合并甲状腺功能异常使病情变得更为复杂,增加母儿不良预后的风险。故在孕前和孕早期对妊娠期甲状腺功能进行筛查,通过以药物为主的治疗手段使孕期甲状腺激素水平保持在正常范围,以及严密的监护等有助于降低妊娠期子痫前期的发病风险,改善子痫前期合并甲状腺功能异常患者的妊娠结局。

Thyroid dysfunction during pregnancy usually presents as hyperthyroidism or hypothyroidism.Untreated thyroid dysfunction in pregnancy can lead to multiple maternal and fetal complications and cause adverse pregnancy outcomes.Both hyperthyroidism and hypothyroidism can increase the risk of preeclampsia.Preeclampsia with abnormal thyroid function makes the disease become more complicated,and increases the risk of poor mother and child prognosis.Therefore,prepregnancy and early pregnancy screening of thyroid function,the use of drug-based therapy to maintain normal levels of thyroid hormone during pregnancy,and strict monitoring are helpful to reduce the risk of preeclampsia during pregnancy,and to improve pregnancy outcomes in preeclampsia patients with thyroid dysfunction.