子痫前期再发的防范

Prevention for recurrent preeclampsia

子痫前期(PE)是造成母儿发病和死亡的常见妊娠期并发症,尽管相比经产妇,其在初产妇人群中的发生率更高。然而,前次妊娠有PE病史者,再次妊娠则属于再发高风险人群,且前次发病孕周越早,或并发子痫、HELLP综合征、胎儿生长受限等,再次发病的概率更高,程度更重。有关PE再发的研究对产科医生极具挑战性,又值再生育人群高峰,如何做好孕前咨询,分层管理,采取合适的预防措施,监测病情和适时分娩,争取母儿利益最大化,是产科医生临床处理的重点。

Preeclampsia is a common pregnancy complication that causes maternal and fetal morbidity and mortality.Although the incidence is higher in nulliparous women than in multiparae,any multipara who has a history of PE bears a higher risk,and if the previous PE is of an early onset,or complicated with eclampsia,HELLP syndrome or FGR,the recurrence risk goes even higher,probably with an even severer degree.The study of the reccurent PE is very challenging for obstetricians. For the multiparous women,the obstetricians should focus on providing a better antenatal counselling,promoting the mothers＇ health,standardizing the prenatal examination,taking comprehensive preventive measures,monitoring the gestational process and delivery timing,so as to maximize the interests of both the mothers and the babies.