急性冠脉综合征合并糖调节受损患者冠脉病变及胰岛素抵抗分析

Analysis of coronary artery disease and insulin resistance in patients with acute coronary syndrome and impaired glucose regulation

目的:探讨急性冠脉综合征合并糖调节受损患者的冠脉病变及胰岛素抵抗情况。方法:收治急性冠脉综合征患者166例,根据是否合并糖调节受损分组,观察1组为急性冠脉综合征合并糖调节受损患者,观察2组为不合并糖调节受损的急性冠脉综合征患者,收治冠脉造影及糖代谢正常者83例为对照组,比较3组的冠脉病变情况、临床生化指标、血清学相关指标。结果:观察1组的Gemini积分、五大临床生化指标、NE、hs-CRP数据均高于观察2组、对照组(P<0.05)。结论:急性冠脉综合征合并糖调节受损患者大血管病变、胰岛素抵抗以及炎性反应更重,临床需尽早进行干预。

Objective：To explore the coronary artery disease and insulin resistance in patients with acute coronary- syndrome and impaired glucose regulation.Methods：166 patients with acute coronary- syndrome were selected.According to whether they had impaired glucose regulation,they were grouped.Patients with acute coronary- syndrome and impaired glucose regulation were selected as the observation 1 group.Patients with acute coronary- syndrome and without impaired glucose regulation were selected as the observation 2 group.83 cases of normal coronary angiography and normal glucose metabolism were selected as the control group.We compared the coronary artery lesions,clinical and biochemical indicators,serological related indicators of three groups. Results：In the observation 1 group,Gemini integral,five clinical biochemical indexes,NE and hs-CRP data were all higher than those in the observation 2 group and the control group（P 〈 0.05）.Conclusion：Macroangiopathy,insulin resistance and inflammatory- reaction in patients with acute coronary syndrome and impaired glucose regulation were more severe,and clinical intervention was required as early as possible.