美托洛尔联合阿托伐他汀治疗老年不稳定性心绞痛的临床研究

Clinical study of metoprolol combined with atorvastatin in the treatment of unstable angina pectoris in the elderly

目的:探讨美托洛尔联合阿托伐他汀治疗老年不稳定性心绞痛的疗效及安全性。方法:收治老年不稳定性心绞痛患者92例,随机分为两组。对照组给予阿托伐他汀片口服治疗,联合组给予阿托伐他汀片、酒石酸美托洛尔片治疗。比较两组治疗前后心绞痛发作频率和持续时间及左室舒张内径(LVDd)、每搏输出量(SV)、射血分数(EF)。记录两组治疗期间的不良反应发生情况。结果:治疗后联合组的SV、EF、显效率、总有效率均明显高于对照组(P<0.05);联合组的心绞痛发作频率及持续时间明显低于对照组(P<0.05)。结论:美托洛尔联合阿托伐他汀治疗老年不稳定性心绞痛能有效提高患者的心功能,降低心绞痛的发作频率及减少持续时间,提高总疗效,且安全、可靠。

Objective：To investigate the efficacy and safety of metoprolol combined with atorvastatin in the treatment of senile unstable angina pectoris.Methods：92 elderly patients with unstable angina pectoris were selected.They were randomly divided into the two groups on average.The control group was given oral administration of atorvastatin.The combination group received atorvastatin tablets and metoprolol tartrate tablets.The frequency and duration of angina pectoris and the left ventricular diastolic diameter（LVDd）,stroke volume（SV）and ejection fraction（EF）were compared between groups before and after treatment.The incidence of adverse reactions during the treatment of the two groups was recorded.Results：After treatment,the SV,EF,effective rate and total effective rate of the combined group were significantly higher than those in the control group（P 〈 0.05）.The frequency and duration of angina pectoris in the combined group were significantly lower than that of the control group（P 〈 0.05）. Conclusion：Metoprolol combined with atorvastatin in the treatment of elderly patients with unstable angina pectoris can effectively improve cardiac function,reduce the frequency and duration of angina peetoris,improve the total efficacy,and it is safe and reliable.