消风散加减方联合中药熏洗治疗老年慢性肛门湿疹的临床研究

Effect of Modified Xiaofeng Powder Combined with Herbal Fumigation on Chronic Anus Eczema in Elderly Patients

目的观察消风散加减方联合中药熏洗治疗老年慢性肛门湿疹的疗效。方法选择本院皮肤科收治的60例老年慢性肛门湿疹患者,采用随机数字表法将患者分为观察组(n=30)和对照组(n=30)。对照组予以局部外用苦参汤熏洗治疗,观察组予以局部外用苦参汤熏洗联合内服消风散加减方治疗,两组均治疗1个月。比较两组治疗总有效率、治疗前后的中医证候改善情况(治疗前后主症积分、次症积分、总积分)、主要临床症状(肛周瘙痒、肛门潮湿、皮损肥厚)改善率及随访6个月期间复发率。结果观察组治疗总有效率为83.3%,显著高于对照组56.7%(P<0.05)。两组治疗后的主症积分、次症积分、总积分较治疗前均显著降低(P<0.05),且观察组显著低于对照组(P<0.05)。观察组主要临床症状(肛周瘙痒、肛门潮湿、皮损肥厚)改善率显著高于对照组(P<0.05)。观察组与对照组随访期间复发率分别为8.0%与29.4%,差异无统计学意义(P>0.05)。结论消风散加减方联合中药熏洗治疗老年慢性肛门湿疹可有效缓解患者肛周瘙痒、肛门潮湿、皮损肥厚症状,疗效优于单纯苦参汤外用熏洗治疗,且复发率低,为理想治疗方案。

Objective To observe the effect of modified Xiaofeng powder combined with herbal fumigationn in the treatment of chronic anus eczema in elderly patients. Methods A total of 60 elderly patients with chronic anus eczema in the department of dermatology in our hospital were selected and randomly divided into the observation group and the control group with 30 cases in each group. The control group was treated with herbal fumigation of Kushen decoction for external use, the observation group was treated with herbal fumigation of Kushen Tang for external use and Xiaofeng powder for oral administration. Both groups were treated for one month. The total effective rate, the improvement of the main symptom score（perianal pruritus, anus wetness and skin lesions）, the recurrence rate during the follow-up period of 6 months were compared between two groups. Results The total effective rate of observation group was 83.3%, which was significantly higher than the 56.7% in control group（P〈0.05）. After treatment, the main symptom score（perianal pruritus, anus wetness and skin lesions） in the observation group were significantly lower than observation group（P〈0.05）. The recurrence rates of the observation group and the control group during follow-up were 8.00% and 29.41%, respectively, the difference was not statistically significant（P〉0.05）. Conclusion The Xiaofeng powder combined with herbal fumigation shows obvious effect and low recurrence rate in treatment of chronic anus eczema.