左乙拉西坦联合盐酸舍曲林治疗癫痫伴抑郁患儿的疗效观察

Curative effect of levetiracetam combined with sertraline hydrochloride on epilepsy children with depression

目的探讨左乙拉西坦联合盐酸舍曲林治疗癫痫伴抑郁症儿童的临床疗效。方法回顾性分析112例6~15岁癫痫伴抑郁症的临床资料,按年龄分为学龄组(6~12岁,56例)和少年组(13~15岁,56例),评估治疗前后癫痫发作频率、认知功能(WISC-CR)、汉密尔顿抑郁量表17项(HAMD-17)、生活质量、身体质量指数(BMI)、不良反应发生率。结果与治疗前相比,两组治疗6、12个月,癫痫发作频率、认知功能、HAMD-17评分、生活质量均显著改善(P<0.05);同时,学龄组癫痫发作频率、认知功能、HAMD-17评分、生活质量均显著优于少年组(P<0.05);两组治疗后BMI、不良反应发生率无统计学差异(P>0.05)。结论采用左乙拉西坦联合盐酸舍曲林治疗癫痫伴抑郁症儿童可获得显著的疗效,其中学龄组疗效优于少年组。

Objective To evaluate the clinical curative effects of levetiracetam combined with sertraline hydrochloride on epilepsychildren with depression. Methods The clinical data of 112 epilepsy children with depression aged 6-15 years, of whom, 56 were 6-12years old （group A） and 56 were13-15 years old （group B）, were analyzed retrospectively. All the children were treated by levetiracetamcombined with sertraline hydrochloride for 12 months. The frequency of seizures, Wechsler intelligence scale for children revised inChina （WISC-CR）, Hamilton Depression Rating Scale 17 （HAMD-17）, and quality of life in children with epilepsy （QOLCE）, body massindex （BMI） and incidence of adverse reactions in both groups were determined and analyzed before and after the treatment. Results Thescores of WISC-CR and QOLCE were significantly higher and the frequency of seizures and the scores of HAMD-17 were significantlylower in both the groups after the treatment than those before the treatment （P〈0.05）. The scores of WISC-CR and QOLCE weresignificantly higher and the frequency of seizures and the scores of HAMD-17 were significantly lower in group A than those in group Bafter the treatment （P〈0.05）. However, there were insignificant differences in the BMI and the incidence of adverse reactions between thetwo groups after the treatment （P〉0.05）. Conclusions The curative effects of levetiracetam combined with sertraline hydrochloride onepilepsy children with depression are good in all the age groups, but their effects on epilepsy children with depression aged 6-12 yearsare better than those on epilepsy children with depression aged 13-15 years.